Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome

Identificador: imarina:9329512

Handle: https://hdl.handle.net/20.500.11797/imarina9329512

Autors:
Shyam, SangeethaGomez-Martinez, CarlosPaz-Graniel, IndiraGaforio, Jose JMartinez-Gonzalez, Miguel AngelCorella, DoloresFito, MontserratMartinez, J AlfredoAlonso-Gomez, Angel MWarnberg, JuliaVioque, JesusRomaguera, DoraLopez-Miranda, JoseEstruch, RamonTinahones, Francisco JSantos-Lozano, Jose ManuelSerra-Majem, J LuisBueno-Cavanillas, AuroraTur, Josep ASanchez, Vicente MartinPinto, XavierRamos, MariaVidal, JosepAlcarria, Maria MarDaimiel, LidiaRos, EmilioFernandez-Aranda, FernandoNishi, Stephanie KRegata, Oscar GarciaToledo, EstefaniaSorli, Jose VCastaner, OlgaGarcia-Rios, AntonioValls-Enguix, RafaelPerez-Farinos, NapoleonZulet, M AngelesRayo-Gago, ElenaCasas, RosaRivera-Izquierdo, MarioTojal-Sierra, LucasDamas-Fuentes, MiguelBuil-Cosiales, PilarFernandez-Carrion, RebecaGoday, AlbertPena-Orihuela, Patricia JCompan-Gabucio, LauraDiez-Espino, JavierTello, SusannaGonzalez-Pinto, Anade la O, VictorDelgado-Rodriguez, MiguelBabio, NancySalas-Salvado, Jordi

Resum:
The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID-19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort.Participants (n = 5486) aged 55-75 years were included in this longitudinal cohort. COVID-19 status (positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology.COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15-40) weeks post-infection [fully adjusted β = 0.65 points, 95% confidence interval (CI) 0.15-1.15; p = 0.011]. This association was particularly prominent in women (β = 1.38 points, 95% CI 0.44-2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II ≥ 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13-2.30, p = 0.008).COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.