Autor segons l'article: Wang, FL; Tessier, AJ; Liang, LM; Wittenbecher, C; Haslam, DE; Fernandez-Duval, G; Eliassen, AH; Rexrode, KM; Tobias, DK; Li, J; Zeleznik, O; Grodstein, F; Martinez-Gonzalez, MA; Salas-Salvado, J; Clish, C; Lee, KH; Sun, Q; Stampfer, MJ; Hu, FB; Guasch-Ferre, M
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Paraules clau: Incident cardiovascular-disease risk pseudouridine prevention ovarian-cancer mediterranean diet expression biomarkers all-cause mortality acylcarnitines
Resum: Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.© 2023. Springer Nature Limited.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physics and astronomy (miscellaneous) Physics and astronomy (all) Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências General physics and astronomy General medicine General chemistry General biochemistry,genetics and molecular biology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Astronomia / física Antropologia / arqueologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Identificador de l'autor: 0000-0003-2700-7459
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nature.com/articles/s41467-023-41515-z
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nature Communications. 14 (1): 5744-5744
Referència de l'ítem segons les normes APA: Wang, FL; Tessier, AJ; Liang, LM; Wittenbecher, C; Haslam, DE; Fernandez-Duval, G; Eliassen, AH; Rexrode, KM; Tobias, DK; Li, J; Zeleznik, O; Grodstei (2023). Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals. Nature Communications, 14(1), 5744-5744. DOI: 10.1038/s41467-023-41515-z
DOI de l'article: 10.1038/s41467-023-41515-z
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV