Articles producció científica> Bioquímica i Biotecnologia

Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals

  • Datos identificativos

    Identificador: imarina:9329936
    Autores:
    Wang, FLTessier, AJLiang, LMWittenbecher, CHaslam, DEFernandez-Duval, GEliassen, AHRexrode, KMTobias, DKLi, JZeleznik, OGrodstein, FMartinez-Gonzalez, MASalas-Salvado, JClish, CLee, KHSun, QStampfer, MJHu, FBGuasch-Ferre, M
    Resumen:
    Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.© 2023. Springer Nature Limited.
  • Otros:

    Autor según el artículo: Wang, FL; Tessier, AJ; Liang, LM; Wittenbecher, C; Haslam, DE; Fernandez-Duval, G; Eliassen, AH; Rexrode, KM; Tobias, DK; Li, J; Zeleznik, O; Grodstein, F; Martinez-Gonzalez, MA; Salas-Salvado, J; Clish, C; Lee, KH; Sun, Q; Stampfer, MJ; Hu, FB; Guasch-Ferre, M
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Salas Salvadó, Jorge
    Palabras clave: Incident cardiovascular-disease risk pseudouridine prevention ovarian-cancer mediterranean diet expression biomarkers all-cause mortality acylcarnitines
    Resumen: Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.© 2023. Springer Nature Limited.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physics and astronomy (miscellaneous) Physics and astronomy (all) Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências General physics and astronomy General medicine General chemistry General biochemistry,genetics and molecular biology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Astronomia / física Antropologia / arqueologia
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: jordi.salas@urv.cat
    Identificador del autor: 0000-0003-2700-7459
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.nature.com/articles/s41467-023-41515-z
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nature Communications. 14 (1): 5744-5744
    Referencia de l'ítem segons les normes APA: Wang, FL; Tessier, AJ; Liang, LM; Wittenbecher, C; Haslam, DE; Fernandez-Duval, G; Eliassen, AH; Rexrode, KM; Tobias, DK; Li, J; Zeleznik, O; Grodstei (2023). Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals. Nature Communications, 14(1), 5744-5744. DOI: 10.1038/s41467-023-41515-z
    DOI del artículo: 10.1038/s41467-023-41515-z
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Chemistry (Miscellaneous),Multidisciplinary Sciences,Physics and Astronomy (Miscellaneous)
    Incident cardiovascular-disease
    risk
    pseudouridine
    prevention
    ovarian-cancer
    mediterranean diet
    expression
    biomarkers
    all-cause mortality
    acylcarnitines
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Physics and astronomy (miscellaneous)
    Physics and astronomy (all)
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geociências
    General physics and astronomy
    General medicine
    General chemistry
    General biochemistry,genetics and molecular biology
    Farmacia
    Engenharias iv
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência da computação
    Chemistry (miscellaneous)
    Chemistry (all)
    Biotecnología
    Biodiversidade
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Astronomia / física
    Antropologia / arqueologia
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