Articles producció científica> Medicina i Cirurgia

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes

  • Dades identificatives

    Identificador: imarina:9330366
    Autors:
    Chang, Sook KyungKohlgruber, Ayano C.Mizoguchi, FumitakaMichelet, XavierWolf, Benjamin J.Wei, KevinLee, Pui Y.Lynch, LydiaDuquette, DanielleCeperuelo-Mallafre, VictoriaBanks, Alexander S.Brenner, Michael B.
    Resum:
    M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other inflammatory cytokines drive inflammation and insulin resistance in obesity. Stromal cells regulate leukocyte responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown. PDGFR alpha(+) stromal cells are major producers of IL-33 in adipose tissue. Here, we show that mesenchymal cadherin-11 modulates stromal fibroblast function. Cadherin-11-deficient mice displayed increased stromal production of IL-33, with concomitant enhancements in ILC2s and M2 macrophages that helped control adipose tissue inflammation. Higher expression levels of IL-33 in cadherin-11-deficient mice mediated ILC2 activation, resulting in higher IL-13 expression levels and M2 macrophage expansion in adipose tissue. Consistent with reduced adipose tissue inflammation, cadherin-11-deficient mice were protected from obesity-induced glucose intolerance and adipose tissue fibrosis. Importantly, anti-cadherin-11 mAb blockade similarly improved inflammation and glycemic control in obese WT mice. These results suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation and thus highlight cadherin-11 as a potential therapeutic target for the management of obesity.
  • Altres:

    Autor segons l'article: Chang, Sook Kyung; Kohlgruber, Ayano C.; Mizoguchi, Fumitaka; Michelet, Xavier; Wolf, Benjamin J.; Wei, Kevin; Lee, Pui Y.; Lynch, Lydia; Duquette, Danielle; Ceperuelo-Mallafre, Victoria; Banks, Alexander S.; Brenner, Michael B.;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Ceperuelo Mallafré, Maria Victoria
    Paraules clau: T-cells Pulmonary-fibrosis Obesity Necrosis-factor-alpha Metabolic disease Lymph-nodes Insulin-resistance Homeostasis Expression Alternatively activated macrophages
    Resum: M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other inflammatory cytokines drive inflammation and insulin resistance in obesity. Stromal cells regulate leukocyte responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown. PDGFR alpha(+) stromal cells are major producers of IL-33 in adipose tissue. Here, we show that mesenchymal cadherin-11 modulates stromal fibroblast function. Cadherin-11-deficient mice displayed increased stromal production of IL-33, with concomitant enhancements in ILC2s and M2 macrophages that helped control adipose tissue inflammation. Higher expression levels of IL-33 in cadherin-11-deficient mice mediated ILC2 activation, resulting in higher IL-13 expression levels and M2 macrophage expansion in adipose tissue. Consistent with reduced adipose tissue inflammation, cadherin-11-deficient mice were protected from obesity-induced glucose intolerance and adipose tissue fibrosis. Importantly, anti-cadherin-11 mAb blockade similarly improved inflammation and glycemic control in obese WT mice. These results suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation and thus highlight cadherin-11 as a potential therapeutic target for the management of obesity.
    Àrees temàtiques: Saúde coletiva Odontología Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: victoria.ceperuelo@urv.cat
    Identificador de l'autor: 0000-0002-4460-9761
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.jci.org/articles/view/86881
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Clinical Investigation. 127 (9): 3306-3318
    Referència de l'ítem segons les normes APA: Chang, Sook Kyung; Kohlgruber, Ayano C.; Mizoguchi, Fumitaka; Michelet, Xavier; Wolf, Benjamin J.; Wei, Kevin; Lee, Pui Y.; Lynch, Lydia; Duquette, Da (2017). Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal Of Clinical Investigation, 127(9), 3306-3318. DOI: 10.1172/JCI86881
    DOI de l'article: 10.1172/JCI86881
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, Research & Experimental
    T-cells
    Pulmonary-fibrosis
    Obesity
    Necrosis-factor-alpha
    Metabolic disease
    Lymph-nodes
    Insulin-resistance
    Homeostasis
    Expression
    Alternatively activated macrophages
    Saúde coletiva
    Odontología
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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