Autor según el artículo: Chang, Sook Kyung; Kohlgruber, Ayano C.; Mizoguchi, Fumitaka; Michelet, Xavier; Wolf, Benjamin J.; Wei, Kevin; Lee, Pui Y.; Lynch, Lydia; Duquette, Danielle; Ceperuelo-Mallafre, Victoria; Banks, Alexander S.; Brenner, Michael B.;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Ceperuelo Mallafré, Maria Victoria
Palabras clave: Alternatively activated macrophages Expression Homeostasis Insulin-resistance Lymph-nodes Metabolic disease Necrosis-factor-alpha Obesity Pulmonary-fibrosis T-cells
Resumen: M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other inflammatory cytokines drive inflammation and insulin resistance in obesity. Stromal cells regulate leukocyte responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown. PDGFR alpha(+) stromal cells are major producers of IL-33 in adipose tissue. Here, we show that mesenchymal cadherin-11 modulates stromal fibroblast function. Cadherin-11-deficient mice displayed increased stromal production of IL-33, with concomitant enhancements in ILC2s and M2 macrophages that helped control adipose tissue inflammation. Higher expression levels of IL-33 in cadherin-11-deficient mice mediated ILC2 activation, resulting in higher IL-13 expression levels and M2 macrophage expansion in adipose tissue. Consistent with reduced adipose tissue inflammation, cadherin-11-deficient mice were protected from obesity-induced glucose intolerance and adipose tissue fibrosis. Importantly, anti-cadherin-11 mAb blockade similarly improved inflammation and glycemic control in obese WT mice. These results suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation and thus highlight cadherin-11 as a potential therapeutic target for the management of obesity.
Áreas temáticas: Biotecnología Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Farmacia General medicine Interdisciplinar Medicina i Medicina ii Medicina veterinaria Medicine (all) Medicine (miscellaneous) Medicine, research & experimental Odontología Saúde coletiva
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: victoria.ceperuelo@urv.cat
Identificador del autor: 0000-0002-4460-9761
Fecha de alta del registro: 2023-10-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.jci.org/articles/view/86881
Referencia al articulo segun fuente origial: Journal Of Clinical Investigation. 127 (9): 3306-3318
Referencia de l'ítem segons les normes APA: Chang, Sook Kyung; Kohlgruber, Ayano C.; Mizoguchi, Fumitaka; Michelet, Xavier; Wolf, Benjamin J.; Wei, Kevin; Lee, Pui Y.; Lynch, Lydia; Duquette, Da (2017). Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal Of Clinical Investigation, 127(9), 3306-3318. DOI: 10.1172/JCI86881
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1172/JCI86881
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications
Repositori URV