Articles producció científica> Medicina i Cirurgia

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes

  • Datos identificativos

    Identificador: imarina:9330366
    Autores:
    Chang, Sook KyungKohlgruber, Ayano C.Mizoguchi, FumitakaMichelet, XavierWolf, Benjamin J.Wei, KevinLee, Pui Y.Lynch, LydiaDuquette, DanielleCeperuelo-Mallafre, VictoriaBanks, Alexander S.Brenner, Michael B.
    Resumen:
    M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other inflammatory cytokines drive inflammation and insulin resistance in obesity. Stromal cells regulate leukocyte responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown. PDGFR alpha(+) stromal cells are major producers of IL-33 in adipose tissue. Here, we show that mesenchymal cadherin-11 modulates stromal fibroblast function. Cadherin-11-deficient mice displayed increased stromal production of IL-33, with concomitant enhancements in ILC2s and M2 macrophages that helped control adipose tissue inflammation. Higher expression levels of IL-33 in cadherin-11-deficient mice mediated ILC2 activation, resulting in higher IL-13 expression levels and M2 macrophage expansion in adipose tissue. Consistent with reduced adipose tissue inflammation, cadherin-11-deficient mice were protected from obesity-induced glucose intolerance and adipose tissue fibrosis. Importantly, anti-cadherin-11 mAb blockade similarly improved inflammation and glycemic control in obese WT mice. These results suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation and thus highlight cadherin-11 as a potential therapeutic target for the management of obesity.
  • Otros:

    Autor según el artículo: Chang, Sook Kyung; Kohlgruber, Ayano C.; Mizoguchi, Fumitaka; Michelet, Xavier; Wolf, Benjamin J.; Wei, Kevin; Lee, Pui Y.; Lynch, Lydia; Duquette, Danielle; Ceperuelo-Mallafre, Victoria; Banks, Alexander S.; Brenner, Michael B.;
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Ceperuelo Mallafré, Maria Victoria
    Palabras clave: T-cells Pulmonary-fibrosis Obesity Necrosis-factor-alpha Metabolic disease Lymph-nodes Insulin-resistance Homeostasis Expression Alternatively activated macrophages
    Resumen: M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other inflammatory cytokines drive inflammation and insulin resistance in obesity. Stromal cells regulate leukocyte responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown. PDGFR alpha(+) stromal cells are major producers of IL-33 in adipose tissue. Here, we show that mesenchymal cadherin-11 modulates stromal fibroblast function. Cadherin-11-deficient mice displayed increased stromal production of IL-33, with concomitant enhancements in ILC2s and M2 macrophages that helped control adipose tissue inflammation. Higher expression levels of IL-33 in cadherin-11-deficient mice mediated ILC2 activation, resulting in higher IL-13 expression levels and M2 macrophage expansion in adipose tissue. Consistent with reduced adipose tissue inflammation, cadherin-11-deficient mice were protected from obesity-induced glucose intolerance and adipose tissue fibrosis. Importantly, anti-cadherin-11 mAb blockade similarly improved inflammation and glycemic control in obese WT mice. These results suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation and thus highlight cadherin-11 as a potential therapeutic target for the management of obesity.
    Áreas temáticas: Saúde coletiva Odontología Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: victoria.ceperuelo@urv.cat
    Identificador del autor: 0000-0002-4460-9761
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.jci.org/articles/view/86881
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Clinical Investigation. 127 (9): 3306-3318
    Referencia de l'ítem segons les normes APA: Chang, Sook Kyung; Kohlgruber, Ayano C.; Mizoguchi, Fumitaka; Michelet, Xavier; Wolf, Benjamin J.; Wei, Kevin; Lee, Pui Y.; Lynch, Lydia; Duquette, Da (2017). Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal Of Clinical Investigation, 127(9), 3306-3318. DOI: 10.1172/JCI86881
    DOI del artículo: 10.1172/JCI86881
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Medicine, Research & Experimental
    T-cells
    Pulmonary-fibrosis
    Obesity
    Necrosis-factor-alpha
    Metabolic disease
    Lymph-nodes
    Insulin-resistance
    Homeostasis
    Expression
    Alternatively activated macrophages
    Saúde coletiva
    Odontología
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
  • Documentos:

  • Cerca a google

    Search to google scholar