Mitochondrial dysfunction

Identificador:  imarina:9330531

Handle: https://hdl.handle.net/20.500.11797/imarina9330531

Autors:  Sanchez, Alba; Garcia-Pardo, Graciano; Gomez-Bertomeu, Frederic; Lopez-Dupla, Miguel; Foguet-Romero, Elisabet; Buzon, Maria Jose; Almirante, Benito; Olona, Montserra; Fernandez-Veledo, Sonia; Vidal, Francesc; Chafino, Silvia; Rull, Anna

Resum:
The metabolic alterations caused by SARS-CoV-2 infection reflect disease progression. To analyze molecules involved in these metabolic changes, a multiomics study was performed using plasma from 103 patients with different degrees of COVID-19 severity during the evolution of the infection. With the increased severity of COVID-19, changes in circulating proteomic, metabolomic, and lipidomic profiles increased. Notably, the group of severe and critical patients with high HRG and ChoE (20:3) and low alpha-ketoglutaric acid levels had a high chance of unfavorable disease evolution (AUC = 0.925). Consequently, patients with the worst prognosis presented alterations in the TCA cycle (mitochondrial dysfunction), lipid metabolism, amino acid biosynthesis, and coagulation. Our findings increase knowledge regarding how SARS-CoV-2 infection affects different metabolic pathways and help in understanding the future consequences of COVID-19 to identify potential therapeutic targets.