Articles producció científica> Medicina i Cirurgia

Mitochondrial dysfunction, lipids metabolism, and amino acid biosynthesis are key pathways for COVID-19 recovery

  • Dades identificatives

    Identificador: imarina:9330531
    Handle: https://hdl.handle.net/20.500.11797/imarina9330531
    Autors:
    Sánchez, AGarcía-Pardo, GGómez-Bertomeu, FLópez-Dupla, MFoguet-Romero, EBuzón, MJAlmirante, BOlona, MFernández-Veledo, SVidal, FChafino, SRull, A
    Resum:
    The metabolic alterations caused by SARS-CoV-2 infection reflect disease progression. To analyze molecules involved in these metabolic changes, a multiomics study was performed using plasma from 103 patients with different degrees of COVID-19 severity during the evolution of the infection. With the increased severity of COVID-19, changes in circulating proteomic, metabolomic, and lipidomic profiles increased. Notably, the group of severe and critical patients with high HRG and ChoE (20:3) and low alpha-ketoglutaric acid levels had a high chance of unfavorable disease evolution (AUC = 0.925). Consequently, patients with the worst prognosis presented alterations in the TCA cycle (mitochondrial dysfunction), lipid metabolism, amino acid biosynthesis, and coagulation. Our findings increase knowledge regarding how SARS-CoV-2 infection affects different metabolic pathways and help in understanding the future consequences of COVID-19 to identify potential therapeutic targets.

  • Altres:

    Autor segons l'article: Sánchez, A; García-Pardo, G; Gómez-Bertomeu, F; López-Dupla, M; Foguet-Romero, E; Buzón, MJ; Almirante, B; Olona, M; Fernández-Veledo, S; Vidal, F; Chafino, S; Rull, A
    Departament: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    Autor/s de la URV: Fernandez Veledo, Sonia / Garcia Pardo, Graciano / Gomez Bertomeu, Frederic-Francesc / López Dupla, Jesús Miguel / Olona Cabases, Maria Montserrat / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Sánchez Marín, Antonio / Vidal Marsal, Francisco
    Paraules clau: Human metabolism Biological sciences
    Resum: The metabolic alterations caused by SARS-CoV-2 infection reflect disease progression. To analyze molecules involved in these metabolic changes, a multiomics study was performed using plasma from 103 patients with different degrees of COVID-19 severity during the evolution of the infection. With the increased severity of COVID-19, changes in circulating proteomic, metabolomic, and lipidomic profiles increased. Notably, the group of severe and critical patients with high HRG and ChoE (20:3) and low alpha-ketoglutaric acid levels had a high chance of unfavorable disease evolution (AUC = 0.925). Consequently, patients with the worst prognosis presented alterations in the TCA cycle (mitochondrial dysfunction), lipid metabolism, amino acid biosynthesis, and coagulation. Our findings increase knowledge regarding how SARS-CoV-2 infection affects different metabolic pathways and help in understanding the future consequences of COVID-19 to identify potential therapeutic targets.
    Àrees temàtiques: Multidisciplinary sciences Multidisciplinary
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: graciano.garcia@urv.cat sonia.fernandez@urv.cat antonio.sanchez@urv.cat frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat francesc.vidal@urv.cat jesusmiguel.lopez@urv.cat
    Identificador de l'autor: 0000-0003-2906-3788 0009-0003-7711-3281 0000-0002-8039-2889 0000-0001-7808-5479 0000-0002-6692-6186 0000-0002-9141-2523
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Iscience. 26 (10): 107948-
    Referència de l'ítem segons les normes APA: Sánchez, A; García-Pardo, G; Gómez-Bertomeu, F; López-Dupla, M; Foguet-Romero, E; Buzón, MJ; Almirante, B; Olona, M; Fernández-Veledo, S; Vidal, F; Ch (2023). Mitochondrial dysfunction, lipids metabolism, and amino acid biosynthesis are key pathways for COVID-19 recovery. Iscience, 26(10), 107948-. DOI: 10.1016/j.isci.2023.107948
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Multidisciplinary,Multidisciplinary Sciences
    Human metabolism
    Biological sciences
    Multidisciplinary sciences
    Multidisciplinary

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