Repositori URV

Autor segons l'article: Motevalizadeh, E; Díaz-López, A; Martín, F; Basora, J; Arija, V

Departament: Ciències Mèdiques Bàsiques Medicina i Cirurgia

Autor/s de la URV: Arija Val, Maria Victoria / Basora Gallisa, Josep / Díaz López, Andres / Martín Lujan, Francisco Manuel / Motevalizadeh, Ehsan

Paraules clau: age eclipses glucose homa-ir insulin resistance mother multiparous obesity pregnancy risk validation weight Eclipses Gestational diabetes-mellitus Insulin resistance Multiparous Parity Pregnancy

Resum: Little is known about whether parity is associated with elevated early-pregnancy IR, or whether overweight/obesity contributes to increasing the possible effect.We determined the associations between parity and glucose metabolism parameters in the first trimester of pregnancy in a Mediterranean pregnant population, and whether these associations are impacted by overweight/obesity.Cross-sectional study of 264 healthy pregnant women from the ECLIPSES study who were recruited at 12 weeks of gestation. At baseline, details on socio-economic status, obstetric history (including parity, i.e., number of births), lifestyle factors, anthropometry, and blood samples were collected. Fasting serum glucose, insulin, and HOMA-IR index were assessed in the first trimester. Elevated IR was defined as the upper HOMA-IR tertile (≥1.58). Multivariable linear regression and Cox regression model with constant time were performed.Parity ranged from 0-4. After multivariable adjustment, the insulin levels (β (% change): 20.92, 95%CI: 4.08, 37.71) and HOMA-IR index (β (% change): 19.72, 95%CI: 2.43, 40.49) were positively associated with parity. Additionally, multiparous women, as compared to nulliparous, were more likely to have higher HOMA-IR levels (primiparous (one birth), β (% change): 16.88, 95%CI: -1.00, 37.99; multiparous (≥2 two births), β (% change): 32.18, 95%CI: 3.56, 68.71), and an increased relative risk (RR) of an elevated IR (primiparous (one birth), RR: 1.55, 95%CI: 1.03, 2.36; multiparous (≥2 two births), RR: 1.72, 95%CI: 1.05, 2.83). The combination of multiparity and overweight/obesity conferred a 3.04-fold increase in the RR of elevated IR, which increased proportionally to the number of parities.This study demonstrates that parity may have a negative impact on early-pregnancy IR and that maternal overweight/obesity appears to further aggravate this relationship.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Àrees temàtiques: Biochemistry Biochemistry (medical) Biotecnología Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Clinical biochemistry Educação física Endocrinology Endocrinology & metabolism Endocrinology, diabetes and metabolism Enfermagem Engenharias ii Farmacia General medicine Interdisciplinar Medicina i Medicina ii Medicina iii Medicine (miscellaneous) Nutrição Odontología Saúde coletiva Sociología

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: victoria.arija@urv.cat josep.basora@urv.cat paco.martin@urv.cat ehsan.motevalizadeh@urv.cat andres.diaz@urv.cat josep.basora@urv.cat ehsan.motevalizadeh@urv.cat

Identificador de l'autor: 0000-0002-1758-0975 0000-0003-0359-3588 0000-0002-8692-7610 0000-0002-7500-5629 0000-0002-8692-7610

Data d'alta del registre: 2024-08-03

Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion

Enllaç font original: https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgad594/7299437?redirectedFrom=fulltext&login=false#no-access-message

Referència a l'article segons font original: Journal Of Clinical Endocrinology & Metabolism. 109 (3): 730-739

Referència de l'ítem segons les normes APA: Motevalizadeh, E; Díaz-López, A; Martín, F; Basora, J; Arija, V (2024). Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study. Journal Of Clinical Endocrinology & Metabolism, 109(3), 730-739. DOI: 10.1210/clinem/dgad594

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

DOI de l'article: 10.1210/clinem/dgad594

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2024

Tipus de publicació: Journal Publications