Author, as appears in the article.: Motevalizadeh, Ehsan; Diaz-Lopez, Andres; Martin, Francisco; Basora, Josep; Arija, Victoria
Department: Ciències Mèdiques Bàsiques; Medicina i Cirurgia
URV's Author/s: Arija Val, Maria Victoria / Basora Gallisa, Josep / Díaz López, Andres / Martín Lujan, Francisco Manuel / Motevalizadeh, Ehsan
Keywords: Pregnant women; Pregnant people; Pregnancy; Parity; Overweight; Obesity; Multiparous; Insulin resistance; Insulin; Humans; Gestational diabetes-mellitus; Female; Eclipses; Cross-sectional studies; Body mass index; Blood glucose; weight; validation; risk; pregnancy; obesity; multiparous; mother; insulin resistance; homa-ir; glucose; eclipses; age
Abstract: Little is known about whether parity is associated with elevated early-pregnancy IR, or whether overweight/obesity contributes to increasing the possible effect.We determined the associations between parity and glucose metabolism parameters in the first trimester of pregnancy in a Mediterranean pregnant population, and whether these associations are impacted by overweight/obesity.Cross-sectional study of 264 healthy pregnant women from the ECLIPSES study who were recruited at 12 weeks of gestation. At baseline, details on socio-economic status, obstetric history (including parity, i.e., number of births), lifestyle factors, anthropometry, and blood samples were collected. Fasting serum glucose, insulin, and HOMA-IR index were assessed in the first trimester. Elevated IR was defined as the upper HOMA-IR tertile (≥1.58). Multivariable linear regression and Cox regression model with constant time were performed.Parity ranged from 0-4. After multivariable adjustment, the insulin levels (β (% change): 20.92, 95%CI: 4.08, 37.71) and HOMA-IR index (β (% change): 19.72, 95%CI: 2.43, 40.49) were positively associated with parity. Additionally, multiparous women, as compared to nulliparous, were more likely to have higher HOMA-IR levels (primiparous (one birth), β (% change): 16.88, 95%CI: -1.00, 37.99; multiparous (≥2 two births), β (% change): 32.18, 95%CI: 3.56, 68.71), and an increased relative risk (RR) of an elevated IR (primiparous (one birth), RR: 1.55, 95%CI: 1.03, 2.36; multiparous (≥2 two births), RR: 1.72, 95%CI: 1.05, 2.83). The combination of multiparity and overweight/obesity conferred a 3.04-fold increase in the RR of elevated IR, which increased proportionally to the number of parities.This study demonstrates that parity may have a negative impact on early-pregnancy IR and that maternal overweight/obesity appears to further aggravate this relationship.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Thematic Areas: Sociología; Saúde coletiva; Odontología; Nutrição; Medicine (miscellaneous); Medicina iii; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Engenharias ii; Enfermagem; Endocrinology, diabetes and metabolism; Endocrinology & metabolism; Endocrinology; Educação física; Clinical biochemistry; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Biotecnología; Biochemistry (medical); Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josep.basora@urv.cat; andres.diaz@urv.cat; ehsan.motevalizadeh@urv.cat; paco.martin@urv.cat; josep.basora@urv.cat; victoria.arija@urv.cat
Record's date: 2025-01-28
Paper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgad594/7299437?redirectedFrom=fulltext&login=false#no-access-message
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Journal Of Clinical Endocrinology & Metabolism. 109 (3): 730-739
APA: Motevalizadeh, Ehsan; Diaz-Lopez, Andres; Martin, Francisco; Basora, Josep; Arija, Victoria (2024). Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study. Journal Of Clinical Endocrinology & Metabolism, 109(3), 730-739. DOI: 10.1210/clinem/dgad594
Article's DOI: 10.1210/clinem/dgad594
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV