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Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study

  • Dades identificatives

    Identificador: imarina:9331786
    Autors:
    Cruz-Rodríguez, JCanals-Sans, JHernández-Martínez, CVoltas-Moreso, NArija, V
    Resum:
    Maternal vitamin B12 deficiency has been associated with disturbed cognitive functioning in offspring at different ages during childhood. However, this association has not been explored in pre-school-age children. The objective of this study was to examine the association between maternal vitamin B12 levels at the beginning and end of pregnancy and cognitive functioning in their children at 4 years of age. This longitudinal prospective study included a subsample of pregnant women and their children aged 4 years (n = 249) who participated in the ECLIPSES Study conducted in the province of Tarragona, Spain, from 2013 to 2017. Maternal vitamin B12 concentrations were determined in the first and third trimesters, and sociodemographic, nutritional and psychological data were collected. The children's cognitive functioning was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) and subtests of the Neuropsychological Assessment of Development (NEPSY-II). The multivariable models showed a significant relationship between vitamin B12 and the working memory index in the first trimester of the pregnancy but not in the third trimester. Children of mothers in the second vitamin B12 level tertile (314-413 pg/mL) (β = 6.468, 95% confidence interval [CI]: = 2.054, 10.882, p = 0.004) and third vitamin B12 level tertile (≥414 pg/mL) (β = 4.703, 95% CI: = 0.292, 9.114, p = 0.037) scored higher in the working memory index of the WPPSI-IV than the children of mothers with vitamin B12 levels in the first tertile (<314 pg/mL). Maintaining an adequate level of maternal vitamin B12 during early pregnancy contributes to improved performance in childhood working memory at 4 years of age.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Lt
  • Altres:

    Autor segons l'article: Cruz-Rodríguez, J; Canals-Sans, J; Hernández-Martínez, C; Voltas-Moreso, N; Arija, V
    Departament: Psicologia
    Autor/s de la URV: Arija Val, Maria Victoria / Canals Sans, Josefa / Cruz Rodríguez, Josue / Hernandez Martinez, Carmen / Voltas Moreso, Núria
    Paraules clau: Vitamin b12 levels Prenatal nutrition Pregnancy Folate-deficiency Eclipses study Cognitive functioning Children's health Child development working-memory women vitamin b12 levels questionnaire prenatal nutrition pregnancy nutrition neurodevelopment infant eclipses study cognitive functioning children's health brain-development
    Resum: Maternal vitamin B12 deficiency has been associated with disturbed cognitive functioning in offspring at different ages during childhood. However, this association has not been explored in pre-school-age children. The objective of this study was to examine the association between maternal vitamin B12 levels at the beginning and end of pregnancy and cognitive functioning in their children at 4 years of age. This longitudinal prospective study included a subsample of pregnant women and their children aged 4 years (n = 249) who participated in the ECLIPSES Study conducted in the province of Tarragona, Spain, from 2013 to 2017. Maternal vitamin B12 concentrations were determined in the first and third trimesters, and sociodemographic, nutritional and psychological data were collected. The children's cognitive functioning was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) and subtests of the Neuropsychological Assessment of Development (NEPSY-II). The multivariable models showed a significant relationship between vitamin B12 and the working memory index in the first trimester of the pregnancy but not in the third trimester. Children of mothers in the second vitamin B12 level tertile (314-413 pg/mL) (β = 6.468, 95% confidence interval [CI]: = 2.054, 10.882, p = 0.004) and third vitamin B12 level tertile (≥414 pg/mL) (β = 4.703, 95% CI: = 0.292, 9.114, p = 0.037) scored higher in the working memory index of the WPPSI-IV than the children of mothers with vitamin B12 levels in the first tertile (<314 pg/mL). Maintaining an adequate level of maternal vitamin B12 during early pregnancy contributes to improved performance in childhood working memory at 4 years of age.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.
    Àrees temàtiques: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Obstetrics and gynecology Nutrition and dietetics Nutrition & dietetics Nutrição Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: nuria.voltas@urv.cat josue.cruz@estudiants.urv.cat carmen.hernandez@urv.cat josefa.canals@urv.cat victoria.arija@urv.cat
    Identificador de l'autor: 0000-0001-8855-0282 0000-0001-6328-8679 0000-0002-6209-9558 0000-0002-1758-0975
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.13580
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Maternal And Child Nutrition. 20 (1): e13580-e13580
    Referència de l'ítem segons les normes APA: Cruz-Rodríguez, J; Canals-Sans, J; Hernández-Martínez, C; Voltas-Moreso, N; Arija, V (2024). Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study. Maternal And Child Nutrition, 20(1), e13580-e13580. DOI: 10.1111/mcn.13580
    DOI de l'article: 10.1111/mcn.13580
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Nutrition & Dietetics,Nutrition and Dietetics,Obstetrics and Gynecology,Pediatrics,Pediatrics, Perinatology and Child Health,Public Health, Environmental and Occupational Health
    Vitamin b12 levels
    Prenatal nutrition
    Pregnancy
    Folate-deficiency
    Eclipses study
    Cognitive functioning
    Children's health
    Child development
    working-memory
    women
    vitamin b12 levels
    questionnaire
    prenatal nutrition
    pregnancy
    nutrition
    neurodevelopment
    infant
    eclipses study
    cognitive functioning
    children's health
    brain-development
    Saúde coletiva
    Public health, environmental and occupational health
    Pediatrics, perinatology and child health
    Pediatrics
    Obstetrics and gynecology
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Enfermagem
    Ciências biológicas ii
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