Autor segons l'article: Castañe, H; Jiménez-Franco, A; Martínez-Navidad, C; Placed-Gallego, C; Cambra-Cortés, V; Perta, AM; París, M; Castillo, DD; Arenas, M; Camps, J; Joven, J
Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/s de la URV: Arenas Prat, Meritxell / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Del Castillo Déjardin, Daniel / Jiménez Franco, Andrea / Joven Maried, Jorge / París Sans, Marta
Paraules clau: Pon1 Polymorphism Plasma Paraoxonase-1 Oxidative stress Obesity Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Morbid obesity Metabolic syndrome Lactonase Insulin-resistance High-density-lipoprotein Gene Cholesterol Cardiovascular-disease Arylesterase
Resum: Paraoxonase-1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). Reduced serum PON1 activity is found in diseases marked by oxidative stress and inflammation, but its role in obesity remains unclear. This study investigated PON1 activities and concentrations in morbidly obese individuals and explored the impacts of the genetic polymorphism PON1 rs662 and non-alcoholic fatty liver disease on enzymatic properties. We recruited 1349 morbidly obese patients undergoing bariatric surgery and 823 non-obese volunteers. PON1-related variables, including arylesterase, paraoxonase, and lactonase activities and PON1 concentrations, were examined. Our results showed that morbidly obese individuals exhibited higher PON1 concentrations but lower enzymatic activities than non-obese individuals. We observed inverse associations of arylesterase and paraoxonase activities with waist circumference (rho = -0.24, p < 0.001, and rho = -0.30, p < 0.001, respectively) and body mass index (rho = -0.15, p = 0.001, and rho = -0.23, p < 0.001), as well as direct associations of arylesterase, paraoxonase, and lactonase activities with HDL cholesterol (rho = 0.11, p = 0.005, rho = 0.20, p < 0.001, and rho = 0.20, p < 0.001). No significant differences were observed regarding metabolic syndrome, type 2 diabetes mellitus, hypertension, dyslipidemia, rs662 polymorphism allele frequencies, or the diagnosis of non-alcoholic steatohepatitis. Nevertheless, correlations were found between certain PON1-related variables, steatosis, and ballooning. In conclusion, changes in PON1-related variables in morbidly obese patients are dependent on the disease itself and HDL levels. The relationships between these variables and specific liver histological changes raise intriguing questions for consideration in future studies.
Àrees temàtiques: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: andrea.jimenez@urv.cat marta.paris@urv.cat jorge.camps@urv.cat danieldel.castillo@urv.cat jorge.joven@urv.cat meritxell.arenas@urv.cat helena.castane@estudiants.urv.cat
Identificador de l'autor: 0000-0002-3165-3640 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-2749-4541 0000-0003-0815-2570
Data d'alta del registre: 2024-03-09
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2076-3921/12/12/2038
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Antioxidants. 12 (12):
Referència de l'ítem segons les normes APA: Castañe, H; Jiménez-Franco, A; Martínez-Navidad, C; Placed-Gallego, C; Cambra-Cortés, V; Perta, AM; París, M; Castillo, DD; Arenas, M; Camps, J; Joven (2023). Serum Arylesterase, Paraoxonase, and Lactonase Activities and Paraoxonase-1 Concentrations in Morbidly Obese Patients and Their Relationship with Non-Alcoholic Steatohepatitis. Antioxidants, 12(12), -. DOI: 10.3390/antiox12122038
DOI de l'article: 10.3390/antiox12122038
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV