Articles producció científica> Química Física i Inorgànica

Stereoselective Control of the Cu Activation of β,β-Diboryl Acrylates for Allylic Coupling Protocols with Concomitant Lactonization

  • Dades identificatives

    Identificador: imarina:9363284
    Autors:
    Pujol, MMéndez, MFernández, E
    Resum:
    The key to a successful C-B activation is to discriminate between two geminal boryl moieties that are exposed to the same reaction conditions. Here we describe a stereoselective C-B activation of beta,beta-diboryl acrylates forming exclusively the (Z)-alpha-borylalkenyl copper(I) key intermediate, for subsequent allylic alkylation reactions. The new borylated (Z)-skipped dienoates followed a feasible iodo-lactonization sequence for the preparation of borylated lactone cores, which can be used in drug discovery.
  • Altres:

    Autor segons l'article: Pujol, M; Méndez, M; Fernández, E
    Departament: Química Física i Inorgànica
    Autor/s de la URV: Fernández Gutiérrez, Maria Elena / Pujol Martí, Mireia
    Paraules clau: Substitution
    Resum: The key to a successful C-B activation is to discriminate between two geminal boryl moieties that are exposed to the same reaction conditions. Here we describe a stereoselective C-B activation of beta,beta-diboryl acrylates forming exclusively the (Z)-alpha-borylalkenyl copper(I) key intermediate, for subsequent allylic alkylation reactions. The new borylated (Z)-skipped dienoates followed a feasible iodo-lactonization sequence for the preparation of borylated lactone cores, which can be used in drug discovery.
    Àrees temàtiques: Química
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: mireia.pujol@urv.cat mariaelena.fernandez@urv.cat
    Identificador de l'autor: 0000-0001-9025-1791
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://pubs.acs.org/doi/full/10.1021/acs.orglett.3c03640
    Referència de l'ítem segons les normes APA: Pujol, M., Méndez, M., & Fernández, E. (2024). Stereoselective Control of the Cu Activation of β,β-Diboryl Acrylates for Allylic Coupling Protocols with Concomitant Lactonization. Organic letters, 26(14), 2821–2826. https://doi.org/10.1021/acs.orglett.3c03640
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1021/acs.orglett.3c03640
    Any de publicació de la revista: 2023
    Tipus de publicació: info:eu-repo/semantics/article
  • Paraules clau:

    Química
    Substitution
    Química
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