meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines

Identificador:  imarina:9453501

Handle: https://hdl.handle.net/20.500.11797/imarina9453501

Autors:  Hartley, WC; Huerta, A; Negredo, JC; Boutureira, O

Resum:
Zincke imines enable the regioselective thiofluoroalkylation of substituted pyridines, providing access to thioalkylated pyridines bearing a range of fluorination patterns. Crucial to the success of this strategy was the use of saccharine-derived thiofluoroalkylating reagents, which, upon reaction with TMSCl, generate electrophilic sulfenyl chlorides.