Articles producció científicaQuímica Analítica i Química Orgànica

meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines

  • Identification data

    Identifier:  imarina:9453501
    Handle: https://hdl.handle.net/20.500.11797/imarina9453501
    Authors:  Hartley, WC; Huerta, A; Negredo, JC; Boutureira, O
    Abstract:
    Zincke imines enable the regioselective thiofluoroalkylation of substituted pyridines, providing access to thioalkylated pyridines bearing a range of fluorination patterns. Crucial to the success of this strategy was the use of saccharine-derived thiofluoroalkylating reagents, which, upon reaction with TMSCl, generate electrophilic sulfenyl chlorides.

  • Others:

    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2025/qo/d5qo00533g
    APA: Hartley, WC; Huerta, A; Negredo, JC; Boutureira, O (2025). meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines. Organic Chemistry Frontiers, 12(17), 4794-4799. DOI: 10.1039/d5qo00533g
    Paper original source: Organic Chemistry Frontiers. 12 (17): 4794-4799
    Article's DOI: 10.1039/d5qo00533g
    Journal publication year: 2025-08-19
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2026-02-13
    URV's Author/s: Boutureira Martín, Omar
    Department: Química Analítica i Química Orgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Hartley, WC; Huerta, A; Negredo, JC; Boutureira, O
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Chemistry, organic, Organic chemistry
    Author's mail: omar.boutureira@urv.cat

  • Keywords:

    Aryl
    Catalyzed synthesis
    Chemistry
    Constants
    Fluorine
    Reagen
    Organic
    Organic Chemistry

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