Articles producció científica> Medicina i Cirurgia

Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation

  • Identification data

    Identifier: PC:1540
    Authors:
    Josep M. AlegretNeus Martínez-MicaeloGerard AragonèsRaúl Beltrán-Debón
    Abstract:
    DOI: 10.1016/j.ijcard.2016.04.184
  • Others:

    Author, as appears in the article.: Josep M. Alegret; Neus Martínez-Micaelo; Gerard Aragonès; Raúl Beltrán-Debón
    Department: Bioquímica i Biotecnologia Medicina i Cirurgia
    URV's Author/s: ALEGRET COLOMÉ, JOSEP MARIA; MARTÍNEZ MICAELO, NIEVES BEATRIZ; ARAGONÈS BARGALLÓ, GERARD; BELTRÁN DEBÓN, RAÚL ALEJANDRO
    Keywords: Abbreviations AVS aortic valve surgery BAV bicuspid aortic valve EMPs endothelial microparticles
    Abstract: Background/objectives The mechanisms underlying aortic dilation in bicuspid aortic valve (BAV) disease are unknown. Circulating endothelial microparticles (EMPs) have emerged as biomarkers of endothelial damage. We sought to evaluate the relationships among EMPs, BAV disease, and aortic dilation. Methods Four evaluations were used. Circulating EMPs (PECAM+, E-selectin+) were compared between BAV patients and tricuspid aortic valve (TAV) control subjects. The variables related to circulating EMPs were investigated in BAV patients. Circulating EMP levels were compared between BAV and TAV patients with a dilated aorta. Finally, circulating EMPs in BAV patients were evaluated over time with respect to aortic valve surgery (AVS) or aortic surgery. Results We observed higher levels of circulating PECAM+ EMPs in the BAV patients than in the control subjects (3.98 ± 0.2 vs. 2.39 ± 0.4 per log PECAM+ EMPs/μl, p = 0.001). Aortic dilation was the most significant variable that correlated with the PECAM+ EMP levels in the BAV patients (β = 0.321, p = 0.008). The BAV patients with aortic dilation exhibited higher PECAM+ EMP levels than the TAV patients with dilated aortas, and this correlation was independent of aortic valve function. We observed a drastic decrease in the circulating PECAM+ EMPs following AVS and aortic root replacement (4.27 ± 0.6 and 1.75 ± 0.3 per log PECAM+ EMPs/μl, p = 0.002). Conclusion The observed pattern of higher circulating PECAM+ EMP levels links BAV disease to endothelial damage and aortic dilation. Circulating PECAM+ EMPs were identified as a biological variable related to aortic dilation in patients with BAV disease.
    Research group: Grup de Recerca en Nutrigenòmica Unitat de Recerca Biomèdica Quimioinformàtica i Nutrició
    Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0167-5273
    Author identifier: N/D; N/D; N/D; N/D
    Record's date: 2016-05-23
    Last page: 41
    Journal volume: 217
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30886-5/abstract#%20
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.ijcard.2016.04.184
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 35
    Publication Type: Article Artículo Article
  • Keywords:

    Cor--Vàlvules--Malalties
    Aorta--Malalties
    Cor--Malalties
    Abbreviations AVS aortic valve surgery
    BAV bicuspid aortic valve
    EMPs endothelial microparticles
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    0167-5273
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