Autor según el artículo: Josep M. Alegret; Neus Martínez-Micaelo; Gerard Aragonès; Raúl Beltrán-Debón

Departamento: Bioquímica i Biotecnologia Medicina i Cirurgia

Autor/es de la URV: ALEGRET COLOMÉ, JOSEP MARIA; MARTÍNEZ MICAELO, NIEVES BEATRIZ; ARAGONÈS BARGALLÓ, GERARD; BELTRÁN DEBÓN, RAÚL ALEJANDRO

Palabras clave: Abbreviations AVS aortic valve surgery BAV bicuspid aortic valve EMPs endothelial microparticles

Resumen: Background/objectives The mechanisms underlying aortic dilation in bicuspid aortic valve (BAV) disease are unknown. Circulating endothelial microparticles (EMPs) have emerged as biomarkers of endothelial damage. We sought to evaluate the relationships among EMPs, BAV disease, and aortic dilation. Methods Four evaluations were used. Circulating EMPs (PECAM+, E-selectin+) were compared between BAV patients and tricuspid aortic valve (TAV) control subjects. The variables related to circulating EMPs were investigated in BAV patients. Circulating EMP levels were compared between BAV and TAV patients with a dilated aorta. Finally, circulating EMPs in BAV patients were evaluated over time with respect to aortic valve surgery (AVS) or aortic surgery. Results We observed higher levels of circulating PECAM+ EMPs in the BAV patients than in the control subjects (3.98 ± 0.2 vs. 2.39 ± 0.4 per log PECAM+ EMPs/μl, p = 0.001). Aortic dilation was the most significant variable that correlated with the PECAM+ EMP levels in the BAV patients (β = 0.321, p = 0.008). The BAV patients with aortic dilation exhibited higher PECAM+ EMP levels than the TAV patients with dilated aortas, and this correlation was independent of aortic valve function. We observed a drastic decrease in the circulating PECAM+ EMPs following AVS and aortic root replacement (4.27 ± 0.6 and 1.75 ± 0.3 per log PECAM+ EMPs/μl, p = 0.002). Conclusion The observed pattern of higher circulating PECAM+ EMP levels links BAV disease to endothelial damage and aortic dilation. Circulating PECAM+ EMPs were identified as a biological variable related to aortic dilation in patients with BAV disease.

Grupo de investigación: Grup de Recerca en Nutrigenòmica Unitat de Recerca Biomèdica Quimioinformàtica i Nutrició

Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0167-5273

Identificador del autor: N/D; N/D; N/D; N/D

Fecha de alta del registro: 2016-05-23

Página final: 41

Volumen de revista: 217

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30886-5/abstract#%20

DOI del artículo: 10.1016/j.ijcard.2016.04.184

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Página inicial: 35

Tipo de publicación: Article Artículo Article