Articles producció científica> Ciències Mèdiques Bàsiques

Brain Radiation Information Data Exchange (BRIDE): Integration of experimental data from low-dose ionising radiation research for pathway discovery

  • Identification data

    Identifier: PC:1654
    Handle: https://hdl.handle.net/20.500.11797/PC1654
    Authors:
    Victoria Linares VidalChristos KarapiperisStefan J. KempfRoel QuintensOmid AzimzadehSimonetta PazzagliaDimitry BazykaPier G. MastroberardinoZacharias G. ScourasSoile TapioMohammed Abderrafi BenotmaneChristos A. Ouzounis
    Abstract:
    DOI: 10.1186/s12859-016-1068-8 URL: http://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-016-1068-8

  • Others:

    Author, as appears in the article.: Victoria Linares Vidal; Christos Karapiperis; Stefan J. Kempf; Roel Quintens; Omid Azimzadeh; Simonetta Pazzaglia; Dimitry Bazyka; Pier G. Mastroberardino; Zacharias G. Scouras; Soile Tapio; Mohammed Abderrafi Benotmane; Christos A. Ouzounis
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: LINARES VIDAL, M. VICTORIA; Christos Karapiperis; Stefan J. Kempf; Roel Quintens; Omid Azimzadeh; Simonetta Pazzaglia; Dimitry Bazyka; Pier G. Mastroberardino; Zacharias G. Scouras; Soile Tapio; Mohammed Abderrafi Benotmane; Christos A. Ouzounis
    Keywords: Data integration systems biology
    Abstract: Background: The underlying molecular processes representing stress responses to low-dose ionising radiation (LDIR) in mammals are just beginning to be understood. In particular, LDIR effects on the brain and their possible association with neurodegenerative disease are currently being explored using omics technologies. Results: We describe a light-weight approach for the storage, analysis and distribution of relevant LDIR omics datasets. The data integration platform, called BRIDE, contains information from the literature as well as experimental information from transcriptomics and proteomics studies. It deploys a hybrid, distributed solution using both local storage and cloud technology. Conclusions: BRIDE can act as a knowledge broker for LDIR researchers, to facilitate molecular research on the systems biology of LDIR response in mammals. Its flexible design can capture a range of experimental information for genomics, epigenomics, transcriptomics, and proteomics. The data collection is available at: <bride.azurewebsites.net>.
    Research group: Laboratori de Toxicologia i Salut Mediambiental
    Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1471-2105
    Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Record's date: 2016-06-09
    Journal volume: 17
    Papper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: Article number 212
    Publication Type: Article Artículo Article

  • Keywords:

    Cervell -- Investigació
    Biologia de sistemes
    Data integration
    systems biology
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    1471-2105

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