Articles producció científica> Medicina i Cirurgia

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

  • Identification data

    Identifier: PC:1858
    Authors:
    Pedro Romero-ArocaMarc Baget-BernaldizAlicia Pareja-RiosMaribel Lopez-GalvezRaul Navarro-GilRaquel Verges
    Abstract:
    DOI: 10.1155/2016/2156273 URL: https://www.hindawi.com/journals/jdr/2016/2156273/ Filiació URV: SI Inclòs a la memòria: SI
  • Others:

    Author, as appears in the article.: Pedro Romero-Aroca; Marc Baget-Bernaldiz; Alicia Pareja-Rios; Maribel Lopez-Galvez; Raul Navarro-Gil; Raquel Verges
    Department: Medicina i Cirurgia
    URV's Author/s: ROMERO AROCA, PEDRO; Marc Baget-Bernaldiz; Alicia Pareja-Rios; Maribel Lopez-Galvez; Raul Navarro-Gil; Raquel Verges
    Keywords: Pathophysiology Diabetic macular edema
    Abstract: Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation. This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs. Current diagnostic techniques do not permit us to differentiate between both etiologies. In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.
    Research group: Grup de Recerca d'Oftalmologia
    Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2314-6745
    Author identifier: N/D; N/D; N/D; N/D; N/D; N/D
    Record's date: 2016-11-02
    Journal volume: 2016
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.hindawi.com/journals/jdr/2016/2156273/
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1155/2016/2156273
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: Art.num. 2156273
    Publication Type: Article Artículo Article
  • Keywords:

    Edema macular
    Diabetis -- Complicacions
    Pathophysiology
    Diabetic macular edema
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    2314-6745
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