Author, as appears in the article.: JOAN VENDRELL; BRUNO MARTINEZ-PEREZ; MIRIAM EJARQUE; CRISTINA GUTIERREZ; CATALINA NUÑEZ-ROA; KELLY ROCHE; ROCIO VILA-BEDMAR; MÓNICA BALLESTEROS; IBON REDONDO-ANGULO; ANNA PLANAVILA; FRANCESC VILLARROYA; SONIA FERNÁNDEZ-VELEDO; ANA MEGÍA
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: VENDRELL ORTEGA, JUAN JOSÉ; BRUNO MARTINEZ-PEREZ; MIRIAM EJARQUE; CRISTINA GUTIERREZ; CATALINA NUÑEZ-ROA; KELLY ROCHE; ROCIO VILA-BEDMAR; MÓNICA BALLESTEROS; IBON REDONDO-ANGULO; ANNA PLANAVILA; FRANCESC VILLARROYA; FERNANDEZ VELEDO, SONIA; MEGÍA COLET, ANA
Keywords: Està en blanc
Abstract: Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.
Research group: Grup de Recerca Biomèdica HJ23
Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1931-5244
Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Record's date: 2016-11-24
Last page: 12
Journal volume: 178
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.translationalres.com/article/S1931-5244(16)30105-0/fulltext
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.trsl.2016.06.012
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: 1
Publication Type: Article Artículo Article
Repositori URV