Autor según el artículo: JOAN VENDRELL; BRUNO MARTINEZ-PEREZ; MIRIAM EJARQUE; CRISTINA GUTIERREZ; CATALINA NUÑEZ-ROA; KELLY ROCHE; ROCIO VILA-BEDMAR; MÓNICA BALLESTEROS; IBON REDONDO-ANGULO; ANNA PLANAVILA; FRANCESC VILLARROYA; SONIA FERNÁNDEZ-VELEDO; ANA MEGÍA

Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia

Autor/es de la URV: VENDRELL ORTEGA, JUAN JOSÉ; BRUNO MARTINEZ-PEREZ; MIRIAM EJARQUE; CRISTINA GUTIERREZ; CATALINA NUÑEZ-ROA; KELLY ROCHE; ROCIO VILA-BEDMAR; MÓNICA BALLESTEROS; IBON REDONDO-ANGULO; ANNA PLANAVILA; FRANCESC VILLARROYA; FERNANDEZ VELEDO, SONIA; MEGÍA COLET, ANA

Palabras clave: Està en blanc

Resumen: Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.

Grupo de investigación: Grup de Recerca Biomèdica HJ23

Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1931-5244

Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D

Fecha de alta del registro: 2016-11-24

Página final: 12

Volumen de revista: 178

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.translationalres.com/article/S1931-5244(16)30105-0/fulltext

DOI del artículo: 10.1016/j.trsl.2016.06.012

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Página inicial: 1

Tipo de publicación: Article Artículo Article