Author, as appears in the article.: Salas-Salvadó, J.; Amor, AJ.; Serra-Mir, M.; Martínez-González, MA.; Corella, D.; Fitó, M.; Estruch, R.; Serra-Majem, L.; Arós, F.; Babio, N.; Ros, E.; Ortega, E.
Department: Bioquímica i Biotecnologia
URV's Author/s: SALAS SALVADÓ, JORGE; Amor, AJ.; Serra-Mir, M.; Martínez-González, MA.; Corella, D.; Fitó, M.; Estruch, R.; Serra-Majem, L.; Arós, F.; BABIO SÁNCHEZ, NANCY ELVIRA; Ros, E.; Ortega, E.
Keywords: Mediterranean diet Cardiovascular risk prediction cardiovascular disease
Abstract: Background-—The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We
assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in
participants, who were predefined as being at high-risk in the PREvencion con DIeta MEDiterranea (PREDIMED) study—a
nutrition-intervention primary prevention trial—and the impact of adherence to the Mediterranean diet on CVD across risk
categories.
Methods and Results-—In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED
participants (aged 55–74 years, 57% women; 48% with type 2 diabetes mellitus). Major CVD events, the primary PREDIMED end
point, were an aggregate of myocardial infarction, stroke, and cardiovascular death. Multivariate-adjusted Cox regression was used
to calculate hazard ratios for major CVD events and effect modification from the Mediterranean diet intervention across risk strata
(low, moderate, high, very high). The Framingham-REGICOR classification of PREDIMED participants was 25.1% low risk, 44.5%
moderate risk, and 30.4% high or very high risk. During 6-year follow-up, 188 major CVD events occurred. Hazard ratios for major
CVD events increased in parallel with estimated risk (2.68, 4.24, and 6.60 for moderate, high, and very high risk), particularly in
men (7.60, 13.16, and 15.85, respectively, versus 2.16, 2.28, and 3.51, respectively, in women). Yet among those with low or
moderate risk, 32.2% and 74.3% of major CVD events occurred in men and women, respectively. Mediterranean diet adherence
was associated with CVD risk reduction regardless of risk strata (P>0.4 for interaction).
Conclusions-—Incident CVD increased in parallel with estimated risk in the PREDIMED cohort, but most events occurred in non–
high-risk categories, particularly in women. Until predictive tools are improved, promotion of the Mediterranean diet might be
useful to reduce CVD independent of baseline risk.
Research group: Alimentació, Nutrició, Creixement i Salut Mental
Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2047-9980
Author identifier: 0000-0003-2700-7459 ; 0000-0003-3527-5277
Record's date: 2018-06-22
Journal volume: 6
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.ahajournals.org/doi/full/10.1161/JAHA.116.004803?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1161/JAHA.116.004803
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Article Artículo Article