Articles producció científica> Ciències Mèdiques Bàsiques

All-cause mortality in the cohorts of the Spanish AIDS Rearch Network (RIS) compared with the general population: 1997-2010

  • Identification data

    Identifier: PC:585
    Handle: https://hdl.handle.net/20.500.11797/PC585
    Authors:
    Hernando, V.Alejos, B.Monge, S.Berenguer, J.Anta, L.Vinuesa, D.Palacios, R.Muga, R.Moreno, S.Jarrin, I.and for CoRIS cohort
    Abstract:
    10.1186/1471-2334-13-382

  • Others:

    Author, as appears in the article.: Hernando, V. Alejos, B. Monge, S. Berenguer, J. Anta, L. Vinuesa, D. Palacios, R. Muga, R. Moreno, S. Jarrin, I. and for CoRIS cohort
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Victoria Hernando, Belen Alejos, Susana Monge, Juan berenguer
    Abstract: Background Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. Methods We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. Results Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997¿2003). Conclusion Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1471-2334
    Last page: 388
    Journal volume: 13
    Papper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili.
    Journal publication year: 2013
    First page: 382