Articles producció científica> Ciències Mèdiques Bàsiques

Body Mass Index and Doses at Organs at Risk in a Mediterranean Population Treated with Postoperative Vaginal Cuff Brachytherapy

  • Identification data

    Identifier: imarina:1962673
    Authors:
    Sabater, SebastiaArenas, MeritxellBerenguer, RobertoAndres, IgnacioJimenez-Jimenez, EstherMartos, AnaFernandez-Lopez, JesusSevillano, MarRovirosa, Angeles
    Abstract:
    Association between body mass index (BMI) and doses in organs at risk during postoperative vaginal cuff brachytherapy (VCB) treatment has not been evaluated. The aim of this study was to analyse the impact of BMI on the dose delivered to bladder and rectum during high-dose-rate VCB using computed tomography (CT) scans at every fraction.A retrospective analysis of 220 planning CT sets derived from 59 patients was conducted. Every planning CT was re-segmented and re-planned under the same parameters. Rectum and bladder dose-volume histogram values (D0.1cc, D1cc, and D2cc) were extracted and evaluated. The mean values for all applications per patient were calculated and correlated with BMI, as well as other factors influencing rectal and bladder doses. Multiple regression analysis performed to model organ at risk dose-volume parameters.According to World Health Organization (WHO), 6.8% of patients were normal, 35.6% were overweight, and 57.6% were class I obese. Median rectal doses were 133.5%, 110.9%, and 99.3% for D0.1cc, D1cc, and D2cc, respectively. The corresponding median bladder doses were 96.2%, 80.6%, and 73.3%, respectively. BMI did not show significant association with rectal doses. However, BMI did show a significant association with evaluated bladder dose metrics (D0.1cc, r=-0.366, p=0.004; D1cc, r=-0.454, p < 0.001; D2cc, r=-0.451, p < 0.001). BMI was retained in the multivariate regression models (D0.1cc, p=0.004; D1cc, p < 0.001; D2cc, p=0.001).In this group of Mediterranean, overweight, and moderately obese patients, BMI showed association with lower bladder dose values, but not with rectal doses.
  • Others:

    Author, as appears in the article.: Sabater, Sebastia; Arenas, Meritxell; Berenguer, Roberto; Andres, Ignacio; Jimenez-Jimenez, Esther; Martos, Ana; Fernandez-Lopez, Jesus; Sevillano, Mar; Rovirosa, Angeles;
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Arenas Prat, Meritxell
    Keywords: Women Waist circumference Urinary bladder Trial Survival Rectum Physical-activity Obesity Mortality Endometrial cancer Brachytherapy Body mass index Adults rectum obesity brachytherapy body mass index
    Abstract: Association between body mass index (BMI) and doses in organs at risk during postoperative vaginal cuff brachytherapy (VCB) treatment has not been evaluated. The aim of this study was to analyse the impact of BMI on the dose delivered to bladder and rectum during high-dose-rate VCB using computed tomography (CT) scans at every fraction.A retrospective analysis of 220 planning CT sets derived from 59 patients was conducted. Every planning CT was re-segmented and re-planned under the same parameters. Rectum and bladder dose-volume histogram values (D0.1cc, D1cc, and D2cc) were extracted and evaluated. The mean values for all applications per patient were calculated and correlated with BMI, as well as other factors influencing rectal and bladder doses. Multiple regression analysis performed to model organ at risk dose-volume parameters.According to World Health Organization (WHO), 6.8% of patients were normal, 35.6% were overweight, and 57.6% were class I obese. Median rectal doses were 133.5%, 110.9%, and 99.3% for D0.1cc, D1cc, and D2cc, respectively. The corresponding median bladder doses were 96.2%, 80.6%, and 73.3%, respectively. BMI did not show significant association with rectal doses. However, BMI did show a significant association with evaluated bladder dose metrics (D0.1cc, r=-0.366, p=0.004; D1cc, r=-0.454, p < 0.001; D2cc, r=-0.451, p < 0.001). BMI was retained in the multivariate regression models (D0.1cc, p=0.004; D1cc, p < 0.001; D2cc, p=0.001).In this group of Mediterranean, overweight, and moderately obese patients, BMI showed association with lower bladder dose values, but not with rectal doses.
    Thematic Areas: Oncology Cancer research
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15982998
    Author's mail: meritxell.arenas@urv.cat
    Author identifier: 0000-0003-0815-2570
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2014.115
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Cancer Research And Treatment. 47 (3): 473-479
    APA: Sabater, Sebastia; Arenas, Meritxell; Berenguer, Roberto; Andres, Ignacio; Jimenez-Jimenez, Esther; Martos, Ana; Fernandez-Lopez, Jesus; Sevillano, Ma (2015). Body Mass Index and Doses at Organs at Risk in a Mediterranean Population Treated with Postoperative Vaginal Cuff Brachytherapy. Cancer Research And Treatment, 47(3), 473-479. DOI: 10.4143/crt.2014.115
    Article's DOI: 10.4143/crt.2014.115
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Cancer Research,Oncology
    Women
    Waist circumference
    Urinary bladder
    Trial
    Survival
    Rectum
    Physical-activity
    Obesity
    Mortality
    Endometrial cancer
    Brachytherapy
    Body mass index
    Adults
    rectum
    obesity
    brachytherapy
    body mass index
    Oncology
    Cancer research
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