Author, as appears in the article.: Corella D., Coltell O., Sorlí J.V., Estruch R., Quiles L., Martínez-González M.Á., Salas-Salvadó J., Castañer O., Arós F., Ortega-Calvo M., Serra-Majem L., Gómez-Gracia E., Portolés O., Fiol M., Espino J.D., Basora J., Fitó M., Ros E., Ordovás J.M.
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
e-ISSN: 2072-6643
URV's Author/s: Basora Gallisa, Josep / Salas Salvadó, Jorge
Keywords: Type-2 diabetes Tcf7l2-predictive value Tcf7l2 T2d-genetic risk scores Predimed study Obesity tcf7l2-predictive value tcf7l2 t2d-genetic risk scores predimed study obesity
Abstract: Nutrigenetic studies analyzing gene-diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential variants in T2D-genetic risk scores (GRS). Therefore, to increase the predictive value (PV) of GRS it is necessary to first see whether the included polymorphisms have heterogeneous effects. We comprehensively investigated gene-obesity interactions between the TCF7L2-rs7903146 C > T polymorphism on T2D (prevalence and incidence) and analyzed other T2D-polymorphisms in a sub-sample. We studied 7018 PREDIMED participants at baseline and longitudinally (8.7 years maximum follow-up). Obesity significantly interacted with the TCF7L2-rs7903146 on T2D prevalence, associations being greater in non-obese subjects. Accordingly, we prospectively observed in non-T2D subjects (n = 3607) that its association with T2D incidence was stronger in non-obese (HR: 1.81; 95% CI: 1.13-2.92, p = 0.013 for TT versus CC) than in obese subjects (HR: 1.01; 95% CI: 0.61-1.66; p = 0.979; p-interaction = 0.048). Accordingly, TCF7L2-PV was higher in non-obese subjects. Additionally, we created obesity-specific GRS with ten T2D-polymorphisms and demonstrated for the first time their higher strata-specific PV. In conclusion, we provide strong evidence supporting the need for considering obesity when analyzing the TCF7L2 effects and propose the use of obesity-specific GRS for T2D.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: thttps://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: josep.basora@urv.cat josep.basora@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-09-07
Journal volume: 8
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/8/12/793
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 8 (12): E793-
APA: Corella D., Coltell O., Sorlí J.V., Estruch R., Quiles L., Martínez-González M.Á., Salas-Salvadó J., Castañer O., Arós F., Ortega-Calvo M., Serra-Maje (2016). Polymorphism of the transcription factor 7-like 2 gene (TCF7L2) interacts with obesity on type-2 diabetes in the predimed study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: Time for obesity-specific genetic risk scores. Nutrients, 8(12), E793-. DOI: 10.3390/nu8120793
Article's DOI: 10.3390/nu8120793
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV