Articles producció científica> Medicina i Cirurgia

Polymorphism of the transcription factor 7-like 2 gene (TCF7L2) interacts with obesity on type-2 diabetes in the predimed study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: Time for obesity-specific genetic risk s

  • Datos identificativos

    Identificador: imarina:2657402
    Handle: http://hdl.handle.net/20.500.11797/imarina2657402
  • Autores:

    Corella D., Coltell O., Sorlí J.V., Estruch R., Quiles L., Martínez-González M.Á., Salas-Salvadó J., Castañer O., Arós F., Ortega-Calvo M., Serra-Majem L., Gómez-Gracia E., Portolés O., Fiol M., Espino J.D., Basora J., Fitó M., Ros E., Ordovás J.M.
  • Otros:

    Autor según el artículo: Corella D., Coltell O., Sorlí J.V., Estruch R., Quiles L., Martínez-González M.Á., Salas-Salvadó J., Castañer O., Arós F., Ortega-Calvo M., Serra-Majem L., Gómez-Gracia E., Portolés O., Fiol M., Espino J.D., Basora J., Fitó M., Ros E., Ordovás J.M.
    Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
    e-ISSN: 2072-6643
    Autor/es de la URV: Basora Gallisa, Josep / Salas Salvadó, Jorge
    Palabras clave: Type-2 diabetes Tcf7l2-predictive value Tcf7l2 T2d-genetic risk scores Predimed study Obesity tcf7l2-predictive value tcf7l2 t2d-genetic risk scores predimed study obesity
    Resumen: Nutrigenetic studies analyzing gene-diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential variants in T2D-genetic risk scores (GRS). Therefore, to increase the predictive value (PV) of GRS it is necessary to first see whether the included polymorphisms have heterogeneous effects. We comprehensively investigated gene-obesity interactions between the TCF7L2-rs7903146 C > T polymorphism on T2D (prevalence and incidence) and analyzed other T2D-polymorphisms in a sub-sample. We studied 7018 PREDIMED participants at baseline and longitudinally (8.7 years maximum follow-up). Obesity significantly interacted with the TCF7L2-rs7903146 on T2D prevalence, associations being greater in non-obese subjects. Accordingly, we prospectively observed in non-T2D subjects (n = 3607) that its association with T2D incidence was stronger in non-obese (HR: 1.81; 95% CI: 1.13-2.92, p = 0.013 for TT versus CC) than in obese subjects (HR: 1.01; 95% CI: 0.61-1.66; p = 0.979; p-interaction = 0.048). Accordingly, TCF7L2-PV was higher in non-obese subjects. Additionally, we created obesity-specific GRS with ten T2D-polymorphisms and demonstrated for the first time their higher strata-specific PV. In conclusion, we provide strong evidence supporting the need for considering obesity when analyzing the TCF7L2 effects and propose the use of obesity-specific GRS for T2D.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    Acceso a la licencia de uso: thttps://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20726643
    Direcció de correo del autor: josep.basora@urv.cat jordi.salas@urv.cat josep.basora@urv.cat
    Identificador del autor: 0000-0003-2700-7459
    Fecha de alta del registro: 2023-02-18
    Volumen de revista: 8
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2072-6643/8/12/793
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nutrients. 8 (12): E793-
    Referencia de l'ítem segons les normes APA: Corella D., Coltell O., Sorlí J.V., Estruch R., Quiles L., Martínez-González M.Á., Salas-Salvadó J., Castañer O., Arós F., Ortega-Calvo M., Serra-Maje (2016). Polymorphism of the transcription factor 7-like 2 gene (TCF7L2) interacts with obesity on type-2 diabetes in the predimed study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: Time for obesity-specific genetic risk scores. Nutrients, 8(12), E793-. DOI: 10.3390/nu8120793
    DOI del artículo: 10.3390/nu8120793
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Type-2 diabetes
    Tcf7l2-predictive value
    Tcf7l2
    T2d-genetic risk scores
    Predimed study
    Obesity
    tcf7l2-predictive value
    tcf7l2
    t2d-genetic risk scores
    predimed study
    obesity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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