Author, as appears in the article.: Guasch-Ferre, Marta; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Ros, Emilio; Corella, Dolores; Estruch, Ramon; Fito, Montserrat; Aros, Fernando; Waernberg, Julia; Fiol, Miquel; Lapetra, Jose; Vinyoles, Ernest; Maria Lamuela-Raventos, Rosa; Serra-Majem, Lluis; Pinto, Xavier; Ruiz-Gutierrez, Valentina; Basora, Josep; Salas-Salvado, Jordi
Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Basora Gallisa, Josep / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Díaz López, Andres / Fernández Ballart, Joan Domènech / Salas Salvadó, Jorge
Keywords: Predimed study Nuts Mortality Cardiovascular Cancer
Abstract: Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person.We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvención con DIeta MEDiterránea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality.During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend<0.05, all). Compared to non-consumers, subjects consuming nuts>3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts>3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66).Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165.Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.
Thematic Areas: Saúde coletiva Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina ii Medicina i General medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 17417015
Author's mail: juanjose.cabre@urv.cat josep.basora@urv.cat andres.diaz@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0003-1082-6861 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-164
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Bmc Medicine. 11 (164): 164-
APA: Guasch-Ferre, Marta; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Ros, Emilio; Corella, Dolores; Estruch, Ramon; Fito, Montserrat; Aros, Fernando; (2013). Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial. Bmc Medicine, 11(164), 164-. DOI: 10.1186/1741-7015-11-164
Article's DOI: 10.1186/1741-7015-11-164
Entity: Universitat Rovira i Virgili
Journal publication year: 2013
Publication Type: Journal Publications
Repositori URV