Author, as appears in the article.: Hernandez-Alonso, Pablo; Canueto, Daniel; Giardin, Simona; Salas-Salvado, Jordi; Canellas, Nicolau; Correig, Xavier; Bullo, Monica;
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Cañellas Alberich, Nicolau / Correig Blanchar, Francesc Xavier / Salas Salvadó, Jorge
Keywords: Prediabetes Pistachios Nuts Microbiota Metabolomics Insulin resistance pistachios nuts microbiota metabolomics insulin resistance
Abstract: The specific nutritional composition of nuts could affect different metabolic pathways involved in a broad range of metabolic diseases. We therefore investigated whether chronic consumption of pistachio nuts modifies the urine metabolome in prediabetic subjects. We designed a randomized crossover clinical trial in 39 prediabetic subjects. They consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57 g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Nuclear magnetic resonance (NRM) was performed to determine changes in 24-h urine metabolites. Significant changes in urine metabolites according to the different intervention periods were found in uni- and multivariate analysis. Score plot of the first two components of the multilevel partial least squares discriminant analysis (ML-PLS-DA) showed a clear separation of the intervention periods. Three metabolites related with gut microbiota metabolism (i.e., hippurate, p-cresol sulfate and dimethylamine) were found decreased in PD compared with CD (P<.05). Moreover, cis-aconitate [intermediate of the tricarboxylic acid (TCA)] was also found decreased following PD compared with CD. Intragroup analysis showed that creatinine levels were significantly increased in PD (P=.023), whereas trimethylamine N-oxide (TMAO) was found significantly reduced following PD (P=.034). Our results suggest that chronic pistachio consumption may modulate some urinary metabolites related to gut microbiota metabolism and the TCA cycle; all associated with metabolic derangements associated with insulin resistance and Type 2 diabetes.
Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Endocrinology, diabetes and metabolism Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09552863
Author's mail: monica.bullo@urv.cat xavier.correig@urv.cat jordi.salas@urv.cat nicolau.canyellas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0002-6902-3054 0000-0003-2700-7459 0000-0003-4856-8132
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0955286316306490
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Nutritional Biochemistry. 45 48-53
APA: Hernandez-Alonso, Pablo; Canueto, Daniel; Giardin, Simona; Salas-Salvado, Jordi; Canellas, Nicolau; Correig, Xavier; Bullo, Monica; (2017). Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects. Journal Of Nutritional Biochemistry, 45(), 48-53. DOI: 10.1016/j.jnutbio.2017.04.002
Article's DOI: 10.1016/j.jnutbio.2017.04.002
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV