Articles producció científica> Bioquímica i Biotecnologia

Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects

  • Datos identificativos

    Identificador: imarina:3654422
    Handle: http://hdl.handle.net/20.500.11797/imarina3654422
  • Autores:

    Hernandez-Alonso, Pablo
    Canueto, Daniel
    Giardin, Simona
    Salas-Salvado, Jordi
    Canellas, Nicolau
    Correig, Xavier
    Bullo, Monica
  • Otros:

    Autor según el artículo: Hernandez-Alonso, Pablo; Canueto, Daniel; Giardin, Simona; Salas-Salvado, Jordi; Canellas, Nicolau; Correig, Xavier; Bullo, Monica;
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Bulló Bonet, Mònica / Cañellas Alberich, Nicolau / Correig Blanchar, Francesc Xavier / Salas Salvadó, Jorge
    Palabras clave: Prediabetes Pistachios Nuts Microbiota Metabolomics Insulin resistance pistachios nuts microbiota metabolomics insulin resistance
    Resumen: The specific nutritional composition of nuts could affect different metabolic pathways involved in a broad range of metabolic diseases. We therefore investigated whether chronic consumption of pistachio nuts modifies the urine metabolome in prediabetic subjects. We designed a randomized crossover clinical trial in 39 prediabetic subjects. They consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57 g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Nuclear magnetic resonance (NRM) was performed to determine changes in 24-h urine metabolites. Significant changes in urine metabolites according to the different intervention periods were found in uni- and multivariate analysis. Score plot of the first two components of the multilevel partial least squares discriminant analysis (ML-PLS-DA) showed a clear separation of the intervention periods. Three metabolites related with gut microbiota metabolism (i.e., hippurate, p-cresol sulfate and dimethylamine) were found decreased in PD compared with CD (P<.05). Moreover, cis-aconitate [intermediate of the tricarboxylic acid (TCA)] was also found decreased following PD compared with CD. Intragroup analysis showed that creatinine levels were significantly increased in PD (P=.023), whereas trimethylamine N-oxide (TMAO) was found significantly reduced following PD (P=.034). Our results suggest that chronic pistachio consumption may modulate some urinary metabolites related to gut microbiota metabolism and the TCA cycle; all associated with metabolic derangements associated with insulin resistance and Type 2 diabetes.
    Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Endocrinology, diabetes and metabolism Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology Biochemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09552863
    Direcció de correo del autor: xavier.correig@urv.cat nicolau.canyellas@urv.cat jordi.salas@urv.cat monica.bullo@urv.cat
    Identificador del autor: 0000-0002-6902-3054 0000-0003-4856-8132 0000-0003-2700-7459 0000-0002-0218-7046
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0955286316306490
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Nutritional Biochemistry. 45 48-53
    Referencia de l'ítem segons les normes APA: Hernandez-Alonso, Pablo; Canueto, Daniel; Giardin, Simona; Salas-Salvado, Jordi; Canellas, Nicolau; Correig, Xavier; Bullo, Monica; (2017). Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects. Journal Of Nutritional Biochemistry, 45(), 48-53. DOI: 10.1016/j.jnutbio.2017.04.002
    DOI del artículo: 10.1016/j.jnutbio.2017.04.002
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Biochemistry & Molecular Biology,Clinical Biochemistry,Endocrinology, Diabetes and Metabolism,Molecular Biology,Nutrition & Dietetics,Nutrition and Dietetics
    Prediabetes
    Pistachios
    Nuts
    Microbiota
    Metabolomics
    Insulin resistance
    pistachios
    nuts
    microbiota
    metabolomics
    insulin resistance
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Molecular biology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
    Biochemistry
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