Articles producció científica> Medicina i Cirurgia

Trace element concentrations in breast cancer patients

  • Identification data

    Identifier: imarina:4028642
    Authors:
    Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL
    Abstract:
    Alterations in the circulating levels of trace elements have been observed in breast cancer (BC) patients. However, the relationships between these alterations and the metabolic and clinical consequences of BC are unknown. The treatment-of-choice of BC is surgery followed by radiation therapy (RT). The present study was aimed at investigating: 1) the concentrations of several trace elements in BC patients, and their relationships with the intrinsic molecular subtypes of tumors; 2) the toxicological effect of RT. We studied 49 women with BC who were scheduled to receive RT following excision of the tumor. Plasma samples were obtained before and after the irradiation procedure. The control group was composed of 49 healthy women. Patients had significantly lower pre-RT concentrations of B, Cu, and Zn, and significantly higher concentrations of Sr than the control group. Irradiation was associated with a striking increase in plasma B concentrations, while Cu, Fe, Sr and Zn concentrations were not significantly different from pre-RT levels, albeit Sr and Zn showed non-significant trends towards increases. The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.Copyright © 2018 Elsevier Ltd. All rights reserved.
  • Others:

    Author, as appears in the article.: Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL
    Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    URV's Author/s: Arenas Prat, Meritxell / Camps Andreu, Jorge / Domingo Roig, José Luis / Joven Maried, Jorge / Nadal Lomas, Martí
    Keywords: Trace elements Radiation therapy Metals Breast cancer trace elements
    Abstract: Alterations in the circulating levels of trace elements have been observed in breast cancer (BC) patients. However, the relationships between these alterations and the metabolic and clinical consequences of BC are unknown. The treatment-of-choice of BC is surgery followed by radiation therapy (RT). The present study was aimed at investigating: 1) the concentrations of several trace elements in BC patients, and their relationships with the intrinsic molecular subtypes of tumors; 2) the toxicological effect of RT. We studied 49 women with BC who were scheduled to receive RT following excision of the tumor. Plasma samples were obtained before and after the irradiation procedure. The control group was composed of 49 healthy women. Patients had significantly lower pre-RT concentrations of B, Cu, and Zn, and significantly higher concentrations of Sr than the control group. Irradiation was associated with a striking increase in plasma B concentrations, while Cu, Fe, Sr and Zn concentrations were not significantly different from pre-RT levels, albeit Sr and Zn showed non-significant trends towards increases. The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.Copyright © 2018 Elsevier Ltd. All rights reserved.
    Thematic Areas: Surgery Sociología Saúde coletiva Oncology Odontología Obstetrics & gynecology Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Educação física Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09609776
    Author's mail: jorge.camps@urv.cat meritxell.arenas@urv.cat jorge.joven@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat
    Author identifier: 0000-0002-3165-3640 0000-0003-0815-2570 0000-0003-2749-4541 0000-0001-6647-9470 0000-0002-0217-4827
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.thebreastonline.com/article/S0960-9776(18)30298-4/abstract
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Breast. 42 142-149
    APA: Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL (2018). Trace element concentrations in breast cancer patients. Breast, 42(), 142-149. DOI: 10.1016/j.breast.2018.09.005
    Article's DOI: 10.1016/j.breast.2018.09.005
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Cancer Research,Medicine (Miscellaneous),Obstetrics & Gynecology,Oncology,Surgery
    Trace elements
    Radiation therapy
    Metals
    Breast cancer
    trace elements
    Surgery
    Sociología
    Saúde coletiva
    Oncology
    Odontología
    Obstetrics & gynecology
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Cancer research
    Biotecnología
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