Articles producció científica> Medicina i Cirurgia

Trace element concentrations in breast cancer patients

  • Datos identificativos

    Identificador: imarina:4028642
    Autores:
    Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL
    Resumen:
    Alterations in the circulating levels of trace elements have been observed in breast cancer (BC) patients. However, the relationships between these alterations and the metabolic and clinical consequences of BC are unknown. The treatment-of-choice of BC is surgery followed by radiation therapy (RT). The present study was aimed at investigating: 1) the concentrations of several trace elements in BC patients, and their relationships with the intrinsic molecular subtypes of tumors; 2) the toxicological effect of RT. We studied 49 women with BC who were scheduled to receive RT following excision of the tumor. Plasma samples were obtained before and after the irradiation procedure. The control group was composed of 49 healthy women. Patients had significantly lower pre-RT concentrations of B, Cu, and Zn, and significantly higher concentrations of Sr than the control group. Irradiation was associated with a striking increase in plasma B concentrations, while Cu, Fe, Sr and Zn concentrations were not significantly different from pre-RT levels, albeit Sr and Zn showed non-significant trends towards increases. The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.Copyright © 2018 Elsevier Ltd. All rights reserved.
  • Otros:

    Autor según el artículo: Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL
    Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    Autor/es de la URV: Arenas Prat, Meritxell / Camps Andreu, Jorge / Domingo Roig, José Luis / Joven Maried, Jorge / Nadal Lomas, Martí
    Palabras clave: Trace elements Radiation therapy Metals Breast cancer trace elements
    Resumen: Alterations in the circulating levels of trace elements have been observed in breast cancer (BC) patients. However, the relationships between these alterations and the metabolic and clinical consequences of BC are unknown. The treatment-of-choice of BC is surgery followed by radiation therapy (RT). The present study was aimed at investigating: 1) the concentrations of several trace elements in BC patients, and their relationships with the intrinsic molecular subtypes of tumors; 2) the toxicological effect of RT. We studied 49 women with BC who were scheduled to receive RT following excision of the tumor. Plasma samples were obtained before and after the irradiation procedure. The control group was composed of 49 healthy women. Patients had significantly lower pre-RT concentrations of B, Cu, and Zn, and significantly higher concentrations of Sr than the control group. Irradiation was associated with a striking increase in plasma B concentrations, while Cu, Fe, Sr and Zn concentrations were not significantly different from pre-RT levels, albeit Sr and Zn showed non-significant trends towards increases. The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.Copyright © 2018 Elsevier Ltd. All rights reserved.
    Áreas temáticas: Surgery Sociología Saúde coletiva Oncology Odontología Obstetrics & gynecology Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Educação física Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09609776
    Direcció de correo del autor: jorge.camps@urv.cat meritxell.arenas@urv.cat jorge.joven@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat
    Identificador del autor: 0000-0002-3165-3640 0000-0003-0815-2570 0000-0003-2749-4541 0000-0001-6647-9470 0000-0002-0217-4827
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.thebreastonline.com/article/S0960-9776(18)30298-4/abstract
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Breast. 42 142-149
    Referencia de l'ítem segons les normes APA: Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL (2018). Trace element concentrations in breast cancer patients. Breast, 42(), 142-149. DOI: 10.1016/j.breast.2018.09.005
    DOI del artículo: 10.1016/j.breast.2018.09.005
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cancer Research,Medicine (Miscellaneous),Obstetrics & Gynecology,Oncology,Surgery
    Trace elements
    Radiation therapy
    Metals
    Breast cancer
    trace elements
    Surgery
    Sociología
    Saúde coletiva
    Oncology
    Odontología
    Obstetrics & gynecology
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Cancer research
    Biotecnología
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