Author, as appears in the article.: Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Toledo, Estefania; Corella, Dolores; Salas-Salvado, Jordi; Cuenca-Royo, Aida; Vioque, Jesus; Romaguera, Dora; Alfredo Martinez, J; Warnberg, Julia; Lopez-Miranda, Jose; Estruch, Ramon; Bueno-Cavanillas, Aurora; Alonso-Gomez, Angel; Tur, Josep A; Tinahones, Francisco J; Serra-Majem, Lluis; Martin, Vicente; Lapetra, Jose; Vazquez, Clotilde; Pinto, Xavier; Vidal, Josep; Daimiel, Lidia; Gaforio, Jose J; Matia, Pilar; Ros, Emilio; Granero, Roser; Buil-Cosiales, Pilar; Barragan, Rocio; Bullo, Monica; Castaner, Olga; Garcia-de-la-Hera, Manoli; Yanez, Aina M; Abete, Itziar; Garcia-Rios, Antonio; Ruiz-Canela, Miguel; Diaz-Lopez, Andres; Jimenez-Murcia, Susana; Martinez-Gonzalez, Miguel A; De la Torre, Rafael; Fernandez-Aranda, Fernando
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Díaz López, Andres / Salas Salvadó, Jorge
Keywords: Women Risk People Mellitus Executive function Decline Cohort Adults
Abstract: This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Author's mail: andres.diaz@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41598-018-33843-8
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Scientific Reports. 8 (1): 16128-
APA: Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Toledo, Estefania; Corella, Dolores; Salas-Salvado, Jordi; Cuenca-Royo, Aida; Vioque, Jesus; Romaguera, (2018). Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. Scientific Reports, 8(1), 16128-. DOI: 10.1038/s41598-018-33843-8
Article's DOI: 10.1038/s41598-018-33843-8
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV