Author, as appears in the article.: Jara-Palomares, Luis; Otero, Remedios; Jimenez, David; Carrier, Marc; Tzoran, Inna; Brenner, Benjamin; Margeli, Mireia; Manuel Praena-Fernandez, Juan; Grandone, Elvira; Monreal, Manuel
Department: Medicina i Cirurgia
URV's Author/s: Auguet Quintillà, Maria Teresa / Porras Ledantes, Jose Antonio
Keywords: Venous thromboembolism Screening Risk Pulmonary embolism Neoplasm screening risk pulmonary embolism neoplasm
Abstract: The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE.We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period.Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ? 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ? 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups.This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
Thematic Areas: Saúde coletiva Respiratory system Química Pulmonary and respiratory medicine Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Economia Critical care medicine Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00123692
Author's mail: joseantonio.porras@urv.cat mariateresa.auguet@urv.cat
Author identifier: 0000-0001-6418-1822 0000-0003-0396-6428
Record's date: 2024-09-28
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://journal.chestnet.org/article/S0012-3692(16)62282-1/fulltext
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Chest. 151 (3): 564-571
APA: Jara-Palomares, Luis; Otero, Remedios; Jimenez, David; Carrier, Marc; Tzoran, Inna; Brenner, Benjamin; Margeli, Mireia; Manuel Praena-Fernandez, Juan; (2017). Development of a Risk Prediction Score for Occult Cancer in Patients With VTE. Chest, 151(3), 564-571. DOI: 10.1016/j.chest.2016.10.025
Article's DOI: 10.1016/j.chest.2016.10.025
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV