Autor según el artículo: Jara-Palomares, Luis; Otero, Remedios; Jimenez, David; Carrier, Marc; Tzoran, Inna; Brenner, Benjamin; Margeli, Mireia; Manuel Praena-Fernandez, Juan; Grandone, Elvira; Monreal, Manuel
Departamento: Medicina i Cirurgia
Autor/es de la URV: Auguet Quintillà, Maria Teresa / Porras Ledantes, Jose Antonio
Palabras clave: Venous thromboembolism Screening Risk Pulmonary embolism Neoplasm screening risk pulmonary embolism neoplasm
Resumen: The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE.We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period.Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ? 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ? 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups.This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
Áreas temáticas: Saúde coletiva Respiratory system Química Pulmonary and respiratory medicine Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Economia Critical care medicine Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00123692
Direcció de correo del autor: joseantonio.porras@urv.cat mariateresa.auguet@urv.cat
Identificador del autor: 0000-0001-6418-1822 0000-0003-0396-6428
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://journal.chestnet.org/article/S0012-3692(16)62282-1/fulltext
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Chest. 151 (3): 564-571
Referencia de l'ítem segons les normes APA: Jara-Palomares, Luis; Otero, Remedios; Jimenez, David; Carrier, Marc; Tzoran, Inna; Brenner, Benjamin; Margeli, Mireia; Manuel Praena-Fernandez, Juan; (2017). Development of a Risk Prediction Score for Occult Cancer in Patients With VTE. Chest, 151(3), 564-571. DOI: 10.1016/j.chest.2016.10.025
DOI del artículo: 10.1016/j.chest.2016.10.025
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications
Repositori URV