Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde

Identifier:  imarina:4684098

Handle: https://hdl.handle.net/20.500.11797/imarina4684098

Authors:  Tomas-Hernandez, Sarah; Garcia-Vallve, Santiago; Pujadas, Gerard; Valls, Cristina; Ojeda-Montes, Maria Jose; Gimeno, Aleix; Cereto-Massague, Adria; Roca-Martinez, Joel; Suarez, Manuel; Arola, Lluis; Blanco, Jordi; Mulero, Miquel; Beltran-Debon, Raul

Abstract:
Metabolic syndrome is a cluster of medical conditions that increases the risk of developing cardiovascular disease and type 2 diabetes. Numerous studies have shown that inflammation is directly involved in the onset of metabolic syndrome and related pathologies. In this study, in silico techniques were applied to a natural products database containing molecules isolated from mushrooms from the Catalan forests to predict molecules that can act as human nuclear-factor κβ kinase 2 (IKK-2) inhibitors. IKK-2 is the main component responsible for activating the nuclear-factor κβ transcription factor (NF-κβ). One of these predicted molecules was o-orsellinaldehyde, a molecule present in the mushroom Grifola frondosa. This study shows that o-orsellinaldehyde presents anti-inflammatory and pro-apoptotic properties by acting as IKK-2 inhibitor. Additionally, we suggest that the anti-inflammatory and pro-apoptotic properties of Grifola frondosa mushroom could partially be explained by the presence of o-orsellinaldehyde on its composition.