Author, as appears in the article.: Tomas-Hernandez, Sarah; Garcia-Vallve, Santiago; Pujadas, Gerard; Valls, Cristina; Ojeda-Montes, Maria Jose; Gimeno, Aleix; Cereto-Massague, Adria; Roca-Martinez, Joel; Suarez, Manuel; Arola, Lluis; Blanco, Jordi; Mulero, Miquel; Beltran-Debon, Raul
Department: Ciències Mèdiques Bàsiques; Bioquímica i Biotecnologia
URV's Author/s: Arola Ferrer, Luis Maria / Beltrán Debón, Raúl Alejandro / Blanco Pérez, Jordi / Cereto Massagué, Adrián José / Garcia Vallve, Santiago / Mulero Abellán, Miguel / OJEDA MONTES, Mª JOSÉ / Pujadas Anguiano, Gerard / Suárez Recio, Manuel / TOMAS HERNÁNDEZ, SARA / Valls Bautista, Cristina
Keywords: Signal transduction; Raw 264.7 cells; Protein serine-threonine kinases; Protein kinase inhibitors; Plant extracts; Phosphorylation; O-orsellinaldehyde; Nf-κβ; Nf-kappab-inducing kinase; Nf-??; Mice, inbred balb c; Mice; Male; Inflammation; Ikk-2; Humans; Grifola frondosa; Grifola; Databases, chemical; Computer simulation; Cell survival; Catechols; Biological products; Apoptosis; Anti-inflammatory agents; Animals; Aldehydes; nf-??; inflammation; ikk-2; grifola frondosa; apoptosis
Abstract: Metabolic syndrome is a cluster of medical conditions that increases the risk of developing cardiovascular disease and type 2 diabetes. Numerous studies have shown that inflammation is directly involved in the onset of metabolic syndrome and related pathologies. In this study, in silico techniques were applied to a natural products database containing molecules isolated from mushrooms from the Catalan forests to predict molecules that can act as human nuclear-factor κβ kinase 2 (IKK-2) inhibitors. IKK-2 is the main component responsible for activating the nuclear-factor κβ transcription factor (NF-κβ). One of these predicted molecules was o-orsellinaldehyde, a molecule present in the mushroom Grifola frondosa. This study shows that o-orsellinaldehyde presents anti-inflammatory and pro-apoptotic properties by acting as IKK-2 inhibitor. Additionally, we suggest that the anti-inflammatory and pro-apoptotic properties of Grifola frondosa mushroom could partially be explained by the presence of o-orsellinaldehyde on its composition.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Planejamento urbano e regional / demografia; Odontología; Nutrição; Medicina veterinaria; Medicina ii; Medicina i; Materiais; Interdisciplinar; General medicine; General chemistry; General agricultural and biological sciences; Food science & technology; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, applied; Chemistry (miscellaneous); Chemistry (all); Biotecnología; Biodiversidade; Astronomia / física; Agriculture, multidisciplinary; Agriculture; Agricultural and biological sciences (miscellaneous); Agricultural and biological sciences (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00218561
Author's mail: adrianjose.cereto@urv.cat; cristina.valls@urv.cat; manuel.suarez@urv.cat; jordi.blanco@urv.cat; miquel.mulero@urv.cat; santi.garcia-vallve@urv.cat; gerard.pujadas@urv.cat; lluis.arola@urv.cat; raul.beltran@urv.cat
Record's date: 2025-02-24
Paper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://pubs.acs.org/doi/10.1021/acs.jafc.8b00782
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Journal Of Agricultural And Food Chemistry. 66 (42): 10952-10963
APA: Tomas-Hernandez, Sarah; Garcia-Vallve, Santiago; Pujadas, Gerard; Valls, Cristina; Ojeda-Montes, Maria Jose; Gimeno, Aleix; Cereto-Massague, Adria; Ro (2018). Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde. Journal Of Agricultural And Food Chemistry, 66(42), 10952-10963. DOI: 10.1021/acs.jafc.8b00782
Article's DOI: 10.1021/acs.jafc.8b00782
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV