Sleep duration is inversely associated with serum uric acid concentrations and uric acid to creatinine ratio in an elderly mediterranean population at high cardiovascular risk

Identifier:  imarina:4899074

Handle: https://hdl.handle.net/20.500.11797/imarina4899074

Authors:  Papandreou, Christopher; Babio, Nancy; Diaz-Lopez, Andres; Martinez-Gonzalez, Miguel A; Becerra-Tomas, Nerea; Corella, Dolores; Schroder, Helmut; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, Alfredo J; Serra-Majem, Lluis; Estruch, Ramon; Munoz-Garach, Araceli; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Garcia-Rios, Antonio; Bueno-Cavanillas, Aurora; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Martin-Sanchez, Vicente; Vidal, Josep; Vazquez, Clotilde; Ros, Emilio; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose V; Quifer, Mireia; Colom, Antoni; Oncina-Canovas, Alejandro; Tojal-Sierra, Lucas; Baron-Lopez, Javier; Perez-Farinos, Napoleon; Abete, Itziar; Sanchez-Villegas, Almudena; Casas, Rosa; Fernandez-Garcia, Jose C; Santos-Lozano, Jose M; Corbella, Emili; Bibiloni, Maria del M; Diez-Espino, Javier; Asensio, Eva M; Torras, Laura; Morey, Marga; Compan-Gabucio, Laura; Salaverria-Lete, Itziar; Cenoz-Osinaga, Juan C; Castaner, Olga; Salas-Salvado, Jordi

Abstract:
The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndromein the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = 0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = 0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.