Articles producció científica> Ciències Mèdiques Bàsiques

Brain Radiation Information Data Exchange (BRIDE): Integration of experimental data from low-dose ionising radiation research for pathway discovery

  • Identification data

    Identifier: imarina:5129816
    Authors:
    Karapiperis, ChristosKempf, Stefan JQuintens, RoelAzimzadeh, OmidVidal, Victoria LinaresPazzaglia, SimonettaBazyka, DimitryMastroberardino, Pier GScouras, Zacharias GTapio, SoileBenotmane, Mohammed AbderrafiOuzounis, Christos A
    Abstract:
    Background: The underlying molecular processes representing stress responses to low-dose ionising radiation (LDIR) in mammals are just beginning to be understood. In particular, LDIR effects on the brain and their possible association with neurodegenerative disease are currently being explored using omics technologies. Results: We describe a light-weight approach for the storage, analysis and distribution of relevant LDIR omics datasets. The data integration platform, called BRIDE, contains information from the literature as well as experimental information from transcriptomics and proteomics studies. It deploys a hybrid, distributed solution using both local storage and cloud technology. Conclusions: BRIDE can act as a knowledge broker for LDIR researchers, to facilitate molecular research on the systems biology of LDIR response in mammals. Its flexible design can capture a range of experimental information for genomics, epigenomics, transcriptomics, and proteomics. The data collection is available at: .
  • Others:

    Author, as appears in the article.: Karapiperis, Christos; Kempf, Stefan J; Quintens, Roel; Azimzadeh, Omid; Vidal, Victoria Linares; Pazzaglia, Simonetta; Bazyka, Dimitry; Mastroberardino, Pier G; Scouras, Zacharias G; Tapio, Soile; Benotmane, Mohammed Abderrafi; Ouzounis, Christos A
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Linares Vidal, M. Victoria
    Keywords: Systems biology Omics technologies Low-dose ionising radiation Data integration Brain research
    Abstract: Background: The underlying molecular processes representing stress responses to low-dose ionising radiation (LDIR) in mammals are just beginning to be understood. In particular, LDIR effects on the brain and their possible association with neurodegenerative disease are currently being explored using omics technologies. Results: We describe a light-weight approach for the storage, analysis and distribution of relevant LDIR omics datasets. The data integration platform, called BRIDE, contains information from the literature as well as experimental information from transcriptomics and proteomics studies. It deploys a hybrid, distributed solution using both local storage and cloud technology. Conclusions: BRIDE can act as a knowledge broker for LDIR researchers, to facilitate molecular research on the systems biology of LDIR response in mammals. Its flexible design can capture a range of experimental information for genomics, epigenomics, transcriptomics, and proteomics. The data collection is available at: .
    Thematic Areas: Structural biology Saúde coletiva Química Molecular biology Medicina veterinaria Medicina ii Medicina i Mathematical & computational biology Matemática / probabilidade e estatística Interdisciplinar Farmacia Engenharias iv Engenharias iii Computer science applications Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biotechnology & applied microbiology Biodiversidade Biochemistry Biochemical research methods Applied mathematics
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14712105
    Author's mail: mvictoria.linares@urv.cat
    Author identifier: 0000-0003-4170-4197
    Record's date: 2024-09-21
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-016-1068-8
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Bmc Bioinformatics. 17 (212): 212-
    APA: Karapiperis, Christos; Kempf, Stefan J; Quintens, Roel; Azimzadeh, Omid; Vidal, Victoria Linares; Pazzaglia, Simonetta; Bazyka, Dimitry; Mastroberardi (2016). Brain Radiation Information Data Exchange (BRIDE): Integration of experimental data from low-dose ionising radiation research for pathway discovery. Bmc Bioinformatics, 17(212), 212-. DOI: 10.1186/s12859-016-1068-8
    Article's DOI: 10.1186/s12859-016-1068-8
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Applied Mathematics,Biochemical Research Methods,Biochemistry,Biotechnology & Applied Microbiology,Computer Science Applications,Mathematical & Computational Biology,Molecular Biology,Structural Biology
    Systems biology
    Omics technologies
    Low-dose ionising radiation
    Data integration
    Brain research
    Structural biology
    Saúde coletiva
    Química
    Molecular biology
    Medicina veterinaria
    Medicina ii
    Medicina i
    Mathematical & computational biology
    Matemática / probabilidade e estatística
    Interdisciplinar
    Farmacia
    Engenharias iv
    Engenharias iii
    Computer science applications
    Ciências sociais aplicadas i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biotechnology & applied microbiology
    Biodiversidade
    Biochemistry
    Biochemical research methods
    Applied mathematics
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