Author, as appears in the article.: Gruszfeld D, Weber M, Gradowska K, Socha P, Grote V, Xhonneux A, Dain E, Verduci E, Riva E, Closa-Monasterolo R, Escribano J, Koletzko B, European Childhood Obesity Study Group.
Department: Medicina i Cirurgia
URV's Author/s: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Gispert Llauradó, Mariona / Luque Moreno, Verònica / RUBIO TORRENTS, MARÍA DEL CARMEN / Zaragoza Jordana, Marta
Keywords: Visceral fat Subcutaneous fat Subcutaneous adipose-tissue Protein Intra-abdominal fat Infant formula Igf-i Growth-factor-i Dietary proteins Computed-tomography Child Body-fat American prepubertal children African-american Abdominal adiposity protein intra-abdominal fat infant formula dietary proteins child
Abstract: Background and aims: The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial.
Methods and results: Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95% CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys.
Conclusions: Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Thematic Areas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: veronica.luque@urv.cat mariona.gispert@urv.cat mariona.gispert@urv.cat marta.zaragoza@urv.cat marta.zaragoza@urv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
Author identifier: 0000-0003-2615-8175 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrition Metabolism And Cardiovascular Diseases. 26 (9): 824-832
APA: Gruszfeld D, Weber M, Gradowska K, Socha P, Grote V, Xhonneux A, Dain E, Verduci E, Riva E, Closa-Monasterolo R, Escribano J, Koletzko B, European Chi (2016). Association of early protein intake and pre-peritoneal fat at five years of age: Follow-up of a randomized clinical trial. Nutrition Metabolism And Cardiovascular Diseases, 26(9), 824-832. DOI: 10.1016/j.numecd.2016.04.005
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV