Articles producció científica> Medicina i Cirurgia

Association of early protein intake and pre-peritoneal fat at five years of age: Follow-up of a randomized clinical trial

  • Datos identificativos

    Identificador: imarina:5130237
    Autores:
    Gruszfeld D, Weber M, Gradowska K, Socha P, Grote V, Xhonneux A, Dain E, Verduci E, Riva E, Closa-Monasterolo R, Escribano J, Koletzko B, European Childhood Obesity Study Group.
    Resumen:
    Background and aims: The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. Methods and results: Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95% CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys. Conclusions: Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
  • Otros:

    Autor según el artículo: Gruszfeld D, Weber M, Gradowska K, Socha P, Grote V, Xhonneux A, Dain E, Verduci E, Riva E, Closa-Monasterolo R, Escribano J, Koletzko B, European Childhood Obesity Study Group.
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Gispert Llauradó, Mariona / Luque Moreno, Verònica / RUBIO TORRENTS, MARÍA DEL CARMEN / Zaragoza Jordana, Marta
    Palabras clave: Visceral fat Subcutaneous fat Subcutaneous adipose-tissue Protein Intra-abdominal fat Infant formula Igf-i Growth-factor-i Dietary proteins Computed-tomography Child Body-fat American prepubertal children African-american Abdominal adiposity protein intra-abdominal fat infant formula dietary proteins child
    Resumen: Background and aims: The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. Methods and results: Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95% CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys. Conclusions: Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
    Áreas temáticas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: veronica.luque@urv.cat mariona.gispert@urv.cat mariona.gispert@urv.cat marta.zaragoza@urv.cat marta.zaragoza@urv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
    Identificador del autor: 0000-0003-2615-8175 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.nmcd-journal.com/article/S0939-4753(15)30136-8/fulltext
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nutrition Metabolism And Cardiovascular Diseases. 26 (9): 824-832
    Referencia de l'ítem segons les normes APA: Gruszfeld D, Weber M, Gradowska K, Socha P, Grote V, Xhonneux A, Dain E, Verduci E, Riva E, Closa-Monasterolo R, Escribano J, Koletzko B, European Chi (2016). Association of early protein intake and pre-peritoneal fat at five years of age: Follow-up of a randomized clinical trial. Nutrition Metabolism And Cardiovascular Diseases, 26(9), 824-832. DOI: 10.1016/j.numecd.2016.04.005
    DOI del artículo: 10.1016/j.numecd.2016.04.005
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Visceral fat
    Subcutaneous fat
    Subcutaneous adipose-tissue
    Protein
    Intra-abdominal fat
    Infant formula
    Igf-i
    Growth-factor-i
    Dietary proteins
    Computed-tomography
    Child
    Body-fat
    American prepubertal children
    African-american
    Abdominal adiposity
    protein
    intra-abdominal fat
    infant formula
    dietary proteins
    child
    Serviço social
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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