Author, as appears in the article.: Serrano, Joan; Casanova-Marti, Angela; Blay, Mayte; Terra, Ximena; Ardevol, Anna; Pinent, Montserrat
Department: Bioquímica i Biotecnologia
e-ISSN: 2072-6643
URV's Author/s: Ardévol Grau, Anna / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Keywords: Synchronicity Proanthocyanidins Hypothalamus Glp-1 Food intake Dose proanthocyanidins hypothalamus glp-1 food intake dose
Abstract: Food intake depends on homeostatic and non-homeostatic factors. In order to use grape seed proanthocyanidins (GSPE) as food intake limiting agents, it is important to define the key characteristics of their bioactivity within this complex function. We treated rats with acute and chronic treatments of GSPE at different doses to identify the importance of eating patterns and GSPE dose and the mechanistic aspects of GSPE. GSPE-induced food intake inhibition must be reproduced under non-stressful conditions and with a stable and synchronized feeding pattern. A minimum dose of around 350 mg GSPE/kg body weight (BW) is needed. GSPE components act by activating the Glucagon-like peptide-1 (GLP-1) receptor because their effect is blocked by Exendin 9-39. GSPE in turn acts on the hypothalamic center of food intake control probably because of increased GLP-1 production in the intestine. To conclude, GSPE inhibits food intake through GLP-1 signaling, but it needs to be dosed under optimal conditions to exert this effect.
Research group: Bioactivitat Molecular dels Aliments
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: thttps://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat
Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378
Record's date: 2024-10-19
Journal volume: 8
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/8/10/652
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 8 (10): 652-
APA: Serrano, Joan; Casanova-Marti, Angela; Blay, Mayte; Terra, Ximena; Ardevol, Anna; Pinent, Montserrat (2016). Defining conditions for optimal inhibition of food intake in rats by a grape-seed derived proanthocyanidin extract. Nutrients, 8(10), 652-. DOI: 10.3390/nu8100652
Article's DOI: 10.3390/nu8100652
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications