Articles producció científica> Química Física i Inorgànica

Surface-Enhanced Raman Scattering Surface Selection Rules for the Proteomic Liquid Biopsy in Real Samples: Efficient Detection of the Oncoprotein c-MYC

  • Identification data

    Identifier: imarina:5130463
  • Authors:

    Pazos, Elena
    Garcia-Algar, Manuel
    Penas, Cristina
    Nazarenus, Moritz
    Torruella, Arnau
    Pazos-Perez, Nicolas
    Guerrini, Luca
    Eugenio Vazquez, M.
    Garcia-Rico, Eduardo
    Mascarenas, Jose L.
    Alvarez-Puebla, Ramon A.
  • Others:

    Author, as appears in the article.: Pazos, Elena; Garcia-Algar, Manuel; Penas, Cristina; Nazarenus, Moritz; Torruella, Arnau; Pazos-Perez, Nicolas; Guerrini, Luca; Eugenio Vazquez, M.; Garcia-Rico, Eduardo; Mascarenas, Jose L.; Alvarez-Puebla, Ramon A.;
    Department: Química Física i Inorgànica
    URV's Author/s: Alvarez Puebla, Ramon Angel / Guerrini, Luca / Pazos Pérez, Nicolás Carlos
    Keywords: Surface enhanced raman scattering Spectroscopy Silver surfaces Sers detection Self-assembled monolayers Raman scattering Protein Path Gold Cells Cancer Biopsy
    Abstract: Blood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of human cancers, can be used as a robust proteomic signature for cancer. Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman scattering (SERS) assay for the quantification of c-MYC in real blood samples. The sensing scheme relies on the use of specifically designed hybrid plasmonic materials and their bioderivatization with a selective peptidic receptor modified with a SERS transducer. Peptide/c-MYC recognition events translate into measurable alterations of the SERS spectra associated with a molecular reorientation of the transducer, in agreement with the surface selection rules. The efficiency of the sensor is demonstrated in cellular lines, healthy donors and a cancer patient.
    Thematic Areas: Química Materiais Interdisciplinar General chemistry Farmacia Engenharias iv Engenharias iii Engenharias ii Colloid and surface chemistry Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Catalysis Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: ramon.alvarez@urv.cat luca.guerrini@urv.cat nicolas.pazos@urv.cat
    Author identifier: 0000-0003-4770-5756 0000-0002-2925-1562 0000-0002-2326-4231
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://pubs.acs.org/doi/10.1021/jacs.6b08957
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of The American Chemical Society. 138 (43): 14206-14209
    APA: Pazos, Elena; Garcia-Algar, Manuel; Penas, Cristina; Nazarenus, Moritz; Torruella, Arnau; Pazos-Perez, Nicolas; Guerrini, Luca; Eugenio Vazquez, M.; G (2016). Surface-Enhanced Raman Scattering Surface Selection Rules for the Proteomic Liquid Biopsy in Real Samples: Efficient Detection of the Oncoprotein c-MYC. Journal Of The American Chemical Society, 138(43), 14206-14209. DOI: 10.1021/jacs.6b08957
    Article's DOI: 10.1021/jacs.6b08957
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Catalysis,Chemistry,Chemistry (Miscellaneous),Chemistry, Multidisciplinary,Colloid and Surface Chemistry
    Surface enhanced raman scattering
    Spectroscopy
    Silver surfaces
    Sers detection
    Self-assembled monolayers
    Raman scattering
    Protein
    Path
    Gold
    Cells
    Cancer
    Biopsy
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Colloid and surface chemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Chemistry
    Catalysis
    Biochemistry
    Astronomia / física
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