Author, as appears in the article.: Fontanals, N.; Marce, R. M.; Borrull, F.;

Department: Química Analítica i Química Orgànica

URV's Author/s: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria

Keywords: Weak cation-exchange Waste-water Urine Synthetic cathinones Solid-phase extraction Solid phase extraction Quantification Psychoactive substances Orbitrap Metabolites Liquid chromatography-orbitrap-high resolution mass spectrometry Liquid chromatography Identification Environmental water samples Designer drugs Derivatives Cathinones Blood Abuse synthetic cathinones solid-phase extraction orbitrap liquid chromatography environmental water samples

Abstract: Synthetic cathinones have become popular in recent years, which would explain why their determination in influent sewage samples has already been documented. In the present study a method based on solid-phase extraction followed by liquid chromatography and high resolution mass spectrometry is developed, validated and applied to determine twelve cathinones and one of their metabolites in different environmental samples including influent and effluent sewage and river water. Two cation-exchange sorbents (Oasis MCX and Oasis WCX) were compared, with better results achieved with Oasis WCX in terms of apparent recoveries (70-100%) and matrix effects (lower than −34%). The method was validated with effluent sewage samples providing suitable figures of merit, with method quantification limits ranging from 1 ng/L to 5 ng/L and method detection limits from 0.1 ng/L to 0.5 ng/L for all the compounds. Of the different cathinones studied, three, namely methylone, mephedrone metabolite and methylenedioxypyrovalerone, were quantified at concentration levels of low ng/L in each of the different samples analysed, while a number of the other cathinones were also detected in some of the samples.

Thematic Areas: Zootecnia / recursos pesqueiros Química Organic chemistry Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Biodiversidade Biochemistry Biochemical research methods Analytical chemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: nuria.fontanals@urv.cat rosamaria.marce@urv.cat francesc.borrull@urv.cat

ISSN: 0021-9673

Author identifier: 0000-0002-7534-1964 0000-0002-5667-2899 0000-0003-2718-9336

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0021967317314590?via%3Dihub

Papper original source: Journal Of Chromatography a. 1524 66-73

APA: Fontanals, N.; Marce, R. M.; Borrull, F.; (2017). Solid-phase extraction followed by liquid chromatography-high resolution mass spectrometry to determine synthetic cathinones in different types of environmental waters samples. Journal Of Chromatography a, 1524(), 66-73. DOI: 10.1016/j.chroma.2017.10.002

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Article's DOI: 10.1016/j.chroma.2017.10.002

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications