Articles producció científica> Ciències Mèdiques Bàsiques

Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa

  • Identification data

    Identifier: imarina:5132648
    Authors:
    Thomson P, López-Fernández L, Guarro J, Capilla J
    Abstract:
    Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.
  • Others:

    Author, as appears in the article.: Thomson P, López-Fernández L, Guarro J, Capilla J
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep
    Keywords: Yeast infections Voriconazole Virulence Triazole Therapy Spp. Rhodotorula mucilaginosa Posaconazole Pharmacodynamics Model Fungemia Candidiasis Antifungal susceptibility therapy rhodotorula mucilaginosa antifungal susceptibility
    Abstract: Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.
    Thematic Areas: Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 07328893
    Author's mail: javier.capilla@urv.cat
    Author identifier: 0000-0002-0765-6403
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0732889317301827
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Diagnostic Microbiology And Infectious Disease. 89 (1): 47-51
    APA: Thomson P, López-Fernández L, Guarro J, Capilla J (2017). Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa. Diagnostic Microbiology And Infectious Disease, 89(1), 47-51. DOI: 10.1016/j.diagmicrobio.2017.06.005
    Article's DOI: 10.1016/j.diagmicrobio.2017.06.005
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical)
    Yeast infections
    Voriconazole
    Virulence
    Triazole
    Therapy
    Spp.
    Rhodotorula mucilaginosa
    Posaconazole
    Pharmacodynamics
    Model
    Fungemia
    Candidiasis
    Antifungal susceptibility
    therapy
    rhodotorula mucilaginosa
    antifungal susceptibility
    Saúde coletiva
    Química
    Odontología
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Infectious diseases
    Farmacia
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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