Author, as appears in the article.: Thomson, Pamela; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep
Keywords: Yeast infections; Voriconazole; Virulence; Triazole; Treatment outcome; Therapy; Spp.; Rhodotorula mucilaginosa; Rhodotorula; Posaconazole; Pharmacodynamics; Mycoses; Model; Mice; Male; Fungemia; Disease models, animal; Colony count, microbial; Candidiasis; Antifungal susceptibility; Antifungal agents; Animals; Animal structures; therapy; rhodotorula mucilaginosa; antifungal susceptibility
Abstract: Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.
Thematic Areas: Saúde coletiva; Química; Odontología; Microbiology (medical); Microbiology; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Infectious diseases; Farmacia; Engenharias ii; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 07328893
Author's mail: javier.capilla@urv.cat
Record's date: 2025-02-08
Paper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0732889317301827
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Diagnostic Microbiology And Infectious Disease. 89 (1): 47-51
APA: Thomson, Pamela; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier (2017). Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa. Diagnostic Microbiology And Infectious Disease, 89(1), 47-51. DOI: 10.1016/j.diagmicrobio.2017.06.005
Article's DOI: 10.1016/j.diagmicrobio.2017.06.005
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV