Autor según el artículo: Thomson, Pamela; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep
Palabras clave: Yeast infections; Voriconazole; Virulence; Triazole; Treatment outcome; Therapy; Spp.; Rhodotorula mucilaginosa; Rhodotorula; Posaconazole; Pharmacodynamics; Mycoses; Model; Mice; Male; Fungemia; Disease models, animal; Colony count, microbial; Candidiasis; Antifungal susceptibility; Antifungal agents; Animals; Animal structures; therapy; rhodotorula mucilaginosa; antifungal susceptibility
Resumen: Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.
Áreas temáticas: Saúde coletiva; Química; Odontología; Microbiology (medical); Microbiology; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Infectious diseases; Farmacia; Engenharias ii; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 07328893
Direcció de correo del autor: javier.capilla@urv.cat
Fecha de alta del registro: 2025-02-08
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0732889317301827
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Diagnostic Microbiology And Infectious Disease. 89 (1): 47-51
Referencia de l'ítem segons les normes APA: Thomson, Pamela; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier (2017). Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa. Diagnostic Microbiology And Infectious Disease, 89(1), 47-51. DOI: 10.1016/j.diagmicrobio.2017.06.005
DOI del artículo: 10.1016/j.diagmicrobio.2017.06.005
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications
Repositori URV