Articles producció científica> Ciències Mèdiques Bàsiques

Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa

  • Datos identificativos

    Identificador: imarina:5132648
    Autores:
    Thomson P, López-Fernández L, Guarro J, Capilla J
    Resumen:
    Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.
  • Otros:

    Autor según el artículo: Thomson P, López-Fernández L, Guarro J, Capilla J
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep
    Palabras clave: Yeast infections Voriconazole Virulence Triazole Therapy Spp. Rhodotorula mucilaginosa Posaconazole Pharmacodynamics Model Fungemia Candidiasis Antifungal susceptibility therapy rhodotorula mucilaginosa antifungal susceptibility
    Resumen: Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.
    Áreas temáticas: Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 07328893
    Direcció de correo del autor: javier.capilla@urv.cat
    Identificador del autor: 0000-0002-0765-6403
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0732889317301827
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Diagnostic Microbiology And Infectious Disease. 89 (1): 47-51
    Referencia de l'ítem segons les normes APA: Thomson P, López-Fernández L, Guarro J, Capilla J (2017). Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa. Diagnostic Microbiology And Infectious Disease, 89(1), 47-51. DOI: 10.1016/j.diagmicrobio.2017.06.005
    DOI del artículo: 10.1016/j.diagmicrobio.2017.06.005
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical)
    Yeast infections
    Voriconazole
    Virulence
    Triazole
    Therapy
    Spp.
    Rhodotorula mucilaginosa
    Posaconazole
    Pharmacodynamics
    Model
    Fungemia
    Candidiasis
    Antifungal susceptibility
    therapy
    rhodotorula mucilaginosa
    antifungal susceptibility
    Saúde coletiva
    Química
    Odontología
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Infectious diseases
    Farmacia
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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