Articles producció científica> Medicina i Cirurgia

Novel circulating biomarkers for non-alcoholic fatty liver disease: A systematic review.

  • Identification data

    Identifier: imarina:5132705
    Authors:
    Sahebkar, AmirhosseinSancho, ElenaAbello, DavidCamps, JordiJoven, Jorge
    Abstract:
    © 2017 Wiley Periodicals, Inc. Currently, a liver biopsy remains the only reliable way to precisely diagnose non-alcoholic fatty liver disease (NAFLD) and establish the severity of liver injury, presence of fibrosis, and architecture remodeling. However, the cost and the intrinsic invasive procedure of a liver biopsy rules it out as a gold standard diagnostic test, and the imaging test are not the best choice due to the price, and currently is being refined. The lack of a biomarker of NAFLD pushes to develop this new line of research. The aim of the present systematic review is to clarify and update all the NAFLD biomarkers described in the literature until recently. We highlight α-ketoglutarate and CK18-F as currently the best potential biomarker of NAFLD. However, due to methodological differences, we propose the implementation of international, multicenter, multiethnic studies with larger population size, and biopsy proven NAFLD diagnosis to analyze and compare α-ketoglutarate and CK18-F as potential biomarkers of the silent evolution of NAFLD.
  • Others:

    Author, as appears in the article.: Sahebkar, Amirhossein; Sancho, Elena; Abello, David; Camps, Jordi; Joven, Jorge;
    Department: Medicina i Cirurgia
    URV's Author/s: Camps Andreu, Jorge / Joven Maried, Jorge
    Keywords: Α-ketoglutarate Non-alcoholic fatty liver disease Diagnosis Ck18-f Biomarker ?-ketoglutarate non-alcoholic fatty liver disease diagnosis ck18-f biomarker
    Abstract: © 2017 Wiley Periodicals, Inc. Currently, a liver biopsy remains the only reliable way to precisely diagnose non-alcoholic fatty liver disease (NAFLD) and establish the severity of liver injury, presence of fibrosis, and architecture remodeling. However, the cost and the intrinsic invasive procedure of a liver biopsy rules it out as a gold standard diagnostic test, and the imaging test are not the best choice due to the price, and currently is being refined. The lack of a biomarker of NAFLD pushes to develop this new line of research. The aim of the present systematic review is to clarify and update all the NAFLD biomarkers described in the literature until recently. We highlight α-ketoglutarate and CK18-F as currently the best potential biomarker of NAFLD. However, due to methodological differences, we propose the implementation of international, multicenter, multiethnic studies with larger population size, and biopsy proven NAFLD diagnosis to analyze and compare α-ketoglutarate and CK18-F as potential biomarkers of the silent evolution of NAFLD.
    Thematic Areas: Química Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cell biology Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00219541
    Author's mail: jorge.camps@urv.cat jorge.joven@urv.cat
    Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.25779
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Cellular Physiology. 233 (2): 849-855
    APA: Sahebkar, Amirhossein; Sancho, Elena; Abello, David; Camps, Jordi; Joven, Jorge; (2018). Novel circulating biomarkers for non-alcoholic fatty liver disease: A systematic review.. Journal Of Cellular Physiology, 233(2), 849-855. DOI: 10.1002/jcp.25779
    Article's DOI: 10.1002/jcp.25779
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Cell Biology,Clinical Biochemistry,Physiology
    Α-ketoglutarate
    Non-alcoholic fatty liver disease
    Diagnosis
    Ck18-f
    Biomarker
    ?-ketoglutarate
    non-alcoholic fatty liver disease
    diagnosis
    ck18-f
    biomarker
    Química
    Physiology
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Enfermagem
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Ciência da computação
    Cell biology
    Biotecnología
    Biodiversidade
  • Documents:

  • Cerca a google

    Search to google scholar