Author, as appears in the article.: Tomas-Roig J, Torrente M, Cabré M, Vilella E, Colomina MT
Department: Bioquímica i Biotecnologia Psicologia
URV's Author/s: Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Torrente Torné, Margarita / Vilella Cuadrada, Elisabet
Keywords: Remyelination Neurobehavioral screening Myelination Motor coordination and anxiety Demyelination Cuprizone neurobehavioral screening motor coordination and anxiety demyelination cuprizone
Abstract: Destruction of the myelin sheath in the central nervous system (CNS) is prominent in many clinico-pathologic conditions. Among animal models that reproduce the pathological features of de- and remyelination processes, the mouse model of cuprizone administration is widely used. Both hyperactivity and motor impairment have been reported upon cuprizone exposure. The aim of the present study was to assess behaviour in mice after CPZ withdrawal.To summarize, animals showed hypo-activity and deficits in motor coordination when they were subjected to acute demyelinating insult while minor exploratory activity, impairment in motor coordination and lower anxiety levels emerged when remyelination was reached following cuprizone withdrawal. A recovery period of 6 weeks after removal of CPZ was not accompanied by a similar return of normal activity indicating long lasting behavioural effects caused by this neurotoxicant. Specifically, the recovery group showed impairments in neurological functions involved in sensorimotor, neuromuscular, motor coordination and the capacity to cope with a stress-inducing event.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Odontología Nutrição Neurosciences Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Filosofia/teologia:subcomissão filosofia Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Behavioral sciences Behavioral neuroscience Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: elisabet.vilella@urv.cat mariateresa.colomina@urv.cat margarita.torrente@urv.cat maria.cabre@urv.cat
ISSN: 01664328
Author identifier: 0000-0002-1887-5919 0000-0002-5619-4874 0000-0002-8901-6345 0000-0003-4124-8603
Record's date: 2023-02-22
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0166432818315948
Papper original source: Behavioural Brain Research. 363 38-44
APA: Tomas-Roig J, Torrente M, Cabré M, Vilella E, Colomina MT (2019). Long lasting behavioural effects on cuprizone fed mice after neurotoxicant withdrawal.. Behavioural Brain Research, 363(), 38-44. DOI: 10.1016/j.bbr.2019.01.036
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.bbr.2019.01.036
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV