Author, as appears in the article.: Parra, S; Cabré, A; Marimon, F; Ferré, R; Ribalta, J; Gonzàlez, M; Heras, M; Castro, A; Masana, L
Department: Medicina i Cirurgia
URV's Author/s: CABRÉ LLOBET, ANNA / Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / HERAS IBAÑEZ, MERCEDES / Marimon Cortes, Francesc / Masana Marín, Luis / Parra Pérez, Sandra / Ribalta Vives, Josep
Keywords: Systemic lupus erythematosus Haematologic Changes Cardiovascular disease systemic lupus erythematosus changes cardiovascular disease
Abstract: The aim of this study is to determine if circulating fatty acid-binding protein 4 (FABP4) plasma levels are a possible marker of metabolic risk in SLE patients. Circulating levels of adipose FABP4 are associated with adiposity, insulin resistance (IR), metabolic syndrome, diabetes and cardiovascular diseases. Patients affected by systemic lupus erythematosus (SLE) show an accelerated atherosclerosis that cannot be entirely explained by traditional cardiovascular risk factors. Sixty consecutive patients with SLE and 34 non-SLE age-matched controls were recruited for the study. Total plasma lipids and circulating FABP4 were determined. Subclinical atherosclerosis was evaluated by measuring carotid intimae-media thickness (c-IMT) by sonography, and the distribution of lipoprotein subclasses was analysed by nuclear magnetic resonance (NMR) spectroscopy. In the SLE group, FABP4 was associated with IR, atherogenic dyslipidaemia, as measured by NMR, and the presence of subclinical atherosclerosis. In multivariate analyses FABP4 was associated with increased c-IMT independent of the inflammatory state of the patient. In sum, circulating FABP4 is involved in the metabolic disturbances of SLE affecting lipid metabolism and IR, and it could be a biomarker of atherosclerosis in this population.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Rheumatology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09612033
Author's mail: francesc.marimon@urv.cat sandra.parra@urv.cat antoni.castro@urv.cat luis.masana@urv.cat josep.ribalta@urv.cat
Author identifier: 0000-0001-9363-6574 0000-0001-5441-6333 0000-0002-0789-4954 0000-0002-8879-4719
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://journals.sagepub.com/doi/10.1177/0961203313517405
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Lupus. 23 (3): 245-254
APA: Parra, S; Cabré, A; Marimon, F; Ferré, R; Ribalta, J; Gonzàlez, M; Heras, M; Castro, A; Masana, L (2014). Circulating FABP4 is a marker of metabolic and cardiovascular risk in SLE patients. Lupus, 23(3), 245-254. DOI: 10.1177/0961203313517405
Article's DOI: 10.1177/0961203313517405
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications