Autor según el artículo: Parra, S; Cabré, A; Marimon, F; Ferré, R; Ribalta, J; Gonzàlez, M; Heras, M; Castro, A; Masana, L
Departamento: Medicina i Cirurgia
Autor/es de la URV: CABRÉ LLOBET, ANNA / Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / HERAS IBAÑEZ, MERCEDES / Marimon Cortes, Francesc / Masana Marín, Luis / Parra Pérez, Sandra / Ribalta Vives, Josep
Palabras clave: Systemic lupus erythematosus Haematologic Changes Cardiovascular disease systemic lupus erythematosus changes cardiovascular disease
Resumen: The aim of this study is to determine if circulating fatty acid-binding protein 4 (FABP4) plasma levels are a possible marker of metabolic risk in SLE patients. Circulating levels of adipose FABP4 are associated with adiposity, insulin resistance (IR), metabolic syndrome, diabetes and cardiovascular diseases. Patients affected by systemic lupus erythematosus (SLE) show an accelerated atherosclerosis that cannot be entirely explained by traditional cardiovascular risk factors. Sixty consecutive patients with SLE and 34 non-SLE age-matched controls were recruited for the study. Total plasma lipids and circulating FABP4 were determined. Subclinical atherosclerosis was evaluated by measuring carotid intimae-media thickness (c-IMT) by sonography, and the distribution of lipoprotein subclasses was analysed by nuclear magnetic resonance (NMR) spectroscopy. In the SLE group, FABP4 was associated with IR, atherogenic dyslipidaemia, as measured by NMR, and the presence of subclinical atherosclerosis. In multivariate analyses FABP4 was associated with increased c-IMT independent of the inflammatory state of the patient. In sum, circulating FABP4 is involved in the metabolic disturbances of SLE affecting lipid metabolism and IR, and it could be a biomarker of atherosclerosis in this population.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Rheumatology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09612033
Direcció de correo del autor: francesc.marimon@urv.cat josep.ribalta@urv.cat luis.masana@urv.cat antoni.castro@urv.cat sandra.parra@urv.cat
Identificador del autor: 0000-0002-8879-4719 0000-0002-0789-4954 0000-0001-5441-6333 0000-0001-9363-6574
Fecha de alta del registro: 2024-02-10
Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
Enlace a la fuente original: https://journals.sagepub.com/doi/10.1177/0961203313517405
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Lupus. 23 (3): 245-254
Referencia de l'ítem segons les normes APA: Parra, S; Cabré, A; Marimon, F; Ferré, R; Ribalta, J; Gonzàlez, M; Heras, M; Castro, A; Masana, L (2014). Circulating FABP4 is a marker of metabolic and cardiovascular risk in SLE patients. Lupus, 23(3), 245-254. DOI: 10.1177/0961203313517405
DOI del artículo: 10.1177/0961203313517405
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2014
Tipo de publicación: Journal Publications
Repositori URV