Articles producció científica> Medicina i Cirurgia

Clinical response to ertapenem in severe community-acquired pneumonia: a retrospective series in an elderly population

  • Identification data

    Identifier: imarina:575110
    Authors:
    Murcia, JMGonzález-Comeche, JMarín, ABarberán, JGranizo, JJAguilar, LGonzález-Moreno, JGonzález-Pina, BLópez-Dupla, MIrurzun, J
    Abstract:
    To evaluate in routine hospital practice the clinical response to ertapenem in comparison with other parenteral antibiotics in the treatment of community-acquired pneumonia (CAP), clinical records from patients with severe CAP treated with ertapenem from July 2002 to June 2006 in seven Spanish hospitals were retrospectively reviewed. Patients were classified according to the Pneumonia Severity Index (PSI). Each ertapenem-treated patient was matched with two patients in the same hospital treated with other antibiotics, according to age (difference 76 years). Comorbidities were present in 193 patients (95.5%). No differences were found in median hospital stay (7 days for ertapenem vs. 10 days for comparators, p 0.066). A slightly higher clinical response rate was obtained for ertapenem vs. comparators (88.7% vs. 77.1%; p 0.0465; OR 2.25; 95% CI 0.99-5.12), with significant differences in clinical response in patients coming from nursing homes (95.8% ertapenem vs. 63.8% comparators; p 0.0034) but not in non-institutionalized patients (85.4% ertapenem vs. 84.5% comparators; p 0.929). The higher clinical response to ertapenem vs. comparators in severe CAP was due to its significantly higher efficacy in healthcare-associated CAP in patients coming from nursing homes.
  • Others:

    Author, as appears in the article.: Murcia, JM; González-Comeche, J; Marín, A; Barberán, J; Granizo, JJ; Aguilar, L; González-Moreno, J; González-Pina, B; López-Dupla, M; Irurzun, J
    Department: Medicina i Cirurgia
    URV's Author/s: López Dupla, Jesús Miguel / Vidal Marsal, Francisco
    Keywords: Therapy Retrospective study Nursing homes Necrosis-factor-alpha Monoclonal-antibody Hospital practice Guidelines Gamma-interferon Ertapenem Elderly Ceftriaxone Cap Adults
    Abstract: To evaluate in routine hospital practice the clinical response to ertapenem in comparison with other parenteral antibiotics in the treatment of community-acquired pneumonia (CAP), clinical records from patients with severe CAP treated with ertapenem from July 2002 to June 2006 in seven Spanish hospitals were retrospectively reviewed. Patients were classified according to the Pneumonia Severity Index (PSI). Each ertapenem-treated patient was matched with two patients in the same hospital treated with other antibiotics, according to age (difference <or=5 years), same PSI class and whether or not resident in a nursing home. Seventy-one patients treated with ertapenem and 131 matched controls were identified; 71 of the 202 patients came from nursing homes. A larger (p 0.0002) number of patients were treated with monotherapy in the ertapenem group. In total, 174 patients (86.1%) belonged to PSI classes IV-V; a higher (p <0.0001) PSI score was found in patients from nursing homes. The mean age was 80.5 years (75% of patients >76 years). Comorbidities were present in 193 patients (95.5%). No differences were found in median hospital stay (7 days for ertapenem vs. 10 days for comparators, p 0.066). A slightly higher clinical response rate was obtained for ertapenem vs. comparators (88.7% vs. 77.1%; p 0.0465; OR 2.25; 95% CI 0.99-5.12), with significant differences in clinical response in patients coming from nursing homes (95.8% ertapenem vs. 63.8% comparators; p 0.0034) but not in non-institutionalized patients (85.4% ertapenem vs. 84.5% comparators; p 0.929). The higher clinical response to ertapenem vs. comparators in severe CAP was due to its significantly higher efficacy in healthcare-associated CAP in patients coming from nursing homes.
    Thematic Areas: Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Infectious diseases Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1198743X
    Author's mail: jesusmiguel.lopez@urv.cat francesc.vidal@urv.cat
    Author identifier: 0000-0002-9141-2523 0000-0002-6692-6186
    Record's date: 2024-02-10
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)61801-2/fulltext
    Papper original source: Clinical Microbiology And Infection. 15 (11): 1046-1050
    APA: Murcia, JM; González-Comeche, J; Marín, A; Barberán, J; Granizo, JJ; Aguilar, L; González-Moreno, J; González-Pina, B; López-Dupla, M; Irurzun, J (2009). Clinical response to ertapenem in severe community-acquired pneumonia: a retrospective series in an elderly population. Clinical Microbiology And Infection, 15(11), 1046-1050. DOI: 10.1111/j.1469-0691.2009.02843.x
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1111/j.1469-0691.2009.02843.x
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2009
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical)
    Therapy
    Retrospective study
    Nursing homes
    Necrosis-factor-alpha
    Monoclonal-antibody
    Hospital practice
    Guidelines
    Gamma-interferon
    Ertapenem
    Elderly
    Ceftriaxone
    Cap
    Adults
    Saúde coletiva
    Química
    Odontología
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Astronomia / física
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