Articles producció científica> Medicina i Cirurgia

Clinical response to ertapenem in severe community-acquired pneumonia: a retrospective series in an elderly population

  • Datos identificativos

    Identificador: imarina:575110
    Autores:
    Murcia, JMGonzález-Comeche, JMarín, ABarberán, JGranizo, JJAguilar, LGonzález-Moreno, JGonzález-Pina, BLópez-Dupla, MIrurzun, J
    Resumen:
    To evaluate in routine hospital practice the clinical response to ertapenem in comparison with other parenteral antibiotics in the treatment of community-acquired pneumonia (CAP), clinical records from patients with severe CAP treated with ertapenem from July 2002 to June 2006 in seven Spanish hospitals were retrospectively reviewed. Patients were classified according to the Pneumonia Severity Index (PSI). Each ertapenem-treated patient was matched with two patients in the same hospital treated with other antibiotics, according to age (difference 76 years). Comorbidities were present in 193 patients (95.5%). No differences were found in median hospital stay (7 days for ertapenem vs. 10 days for comparators, p 0.066). A slightly higher clinical response rate was obtained for ertapenem vs. comparators (88.7% vs. 77.1%; p 0.0465; OR 2.25; 95% CI 0.99-5.12), with significant differences in clinical response in patients coming from nursing homes (95.8% ertapenem vs. 63.8% comparators; p 0.0034) but not in non-institutionalized patients (85.4% ertapenem vs. 84.5% comparators; p 0.929). The higher clinical response to ertapenem vs. comparators in severe CAP was due to its significantly higher efficacy in healthcare-associated CAP in patients coming from nursing homes.
  • Otros:

    Autor según el artículo: Murcia, JM; González-Comeche, J; Marín, A; Barberán, J; Granizo, JJ; Aguilar, L; González-Moreno, J; González-Pina, B; López-Dupla, M; Irurzun, J
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: López Dupla, Jesús Miguel / Vidal Marsal, Francisco
    Palabras clave: Therapy Retrospective study Nursing homes Necrosis-factor-alpha Monoclonal-antibody Hospital practice Guidelines Gamma-interferon Ertapenem Elderly Ceftriaxone Cap Adults
    Resumen: To evaluate in routine hospital practice the clinical response to ertapenem in comparison with other parenteral antibiotics in the treatment of community-acquired pneumonia (CAP), clinical records from patients with severe CAP treated with ertapenem from July 2002 to June 2006 in seven Spanish hospitals were retrospectively reviewed. Patients were classified according to the Pneumonia Severity Index (PSI). Each ertapenem-treated patient was matched with two patients in the same hospital treated with other antibiotics, according to age (difference <or=5 years), same PSI class and whether or not resident in a nursing home. Seventy-one patients treated with ertapenem and 131 matched controls were identified; 71 of the 202 patients came from nursing homes. A larger (p 0.0002) number of patients were treated with monotherapy in the ertapenem group. In total, 174 patients (86.1%) belonged to PSI classes IV-V; a higher (p <0.0001) PSI score was found in patients from nursing homes. The mean age was 80.5 years (75% of patients >76 years). Comorbidities were present in 193 patients (95.5%). No differences were found in median hospital stay (7 days for ertapenem vs. 10 days for comparators, p 0.066). A slightly higher clinical response rate was obtained for ertapenem vs. comparators (88.7% vs. 77.1%; p 0.0465; OR 2.25; 95% CI 0.99-5.12), with significant differences in clinical response in patients coming from nursing homes (95.8% ertapenem vs. 63.8% comparators; p 0.0034) but not in non-institutionalized patients (85.4% ertapenem vs. 84.5% comparators; p 0.929). The higher clinical response to ertapenem vs. comparators in severe CAP was due to its significantly higher efficacy in healthcare-associated CAP in patients coming from nursing homes.
    Áreas temáticas: Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Infectious diseases Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1198743X
    Direcció de correo del autor: jesusmiguel.lopez@urv.cat francesc.vidal@urv.cat
    Identificador del autor: 0000-0002-9141-2523 0000-0002-6692-6186
    Fecha de alta del registro: 2024-02-10
    Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
    Enlace a la fuente original: https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)61801-2/fulltext
    Referencia al articulo segun fuente origial: Clinical Microbiology And Infection. 15 (11): 1046-1050
    Referencia de l'ítem segons les normes APA: Murcia, JM; González-Comeche, J; Marín, A; Barberán, J; Granizo, JJ; Aguilar, L; González-Moreno, J; González-Pina, B; López-Dupla, M; Irurzun, J (2009). Clinical response to ertapenem in severe community-acquired pneumonia: a retrospective series in an elderly population. Clinical Microbiology And Infection, 15(11), 1046-1050. DOI: 10.1111/j.1469-0691.2009.02843.x
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1111/j.1469-0691.2009.02843.x
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2009
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical)
    Therapy
    Retrospective study
    Nursing homes
    Necrosis-factor-alpha
    Monoclonal-antibody
    Hospital practice
    Guidelines
    Gamma-interferon
    Ertapenem
    Elderly
    Ceftriaxone
    Cap
    Adults
    Saúde coletiva
    Química
    Odontología
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Astronomia / física
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