Author, as appears in the article.: Rodriguez-Tomas, Elisabet; Murcia, Mauricio; Arenas, Meritxell; Arguis, Monica; Gil, Miriam; Amigo, Nuria; Correig, Xavier; Torres, Laura; Sabater, Sebastia; Baiges-Gaya, Gerard; Cabre, Noemi; Luciano-Mateo, Fedra; Hernandez-Aguilera, Anna; Fort-Gallifa, Isabel; Camps, Jordi; Joven, Jorge;
Department: Medicina i Cirurgia Enginyeria Electrònica, Elèctrica i Automàtica
e-ISSN: 2076-3921
URV's Author/s: Arenas Prat, Meritxell / Arguis Pinel, Mònica / Camps Andreu, Jorge / Correig Blanchar, Francesc Xavier / Joven Maried, Jorge / Murcia Mejia, Mauricio
Keywords: Radiotherapy Paraoxonase-1 Lung cancer Lipoproteins Head and neck cancer Antioxidants paraoxonase-1 lung cancer lipoproteins head and neck cancer antioxidants
Abstract: We investigated alterations in the levels of the antioxidant paraoxonase-1 (PON1) and the lipoprotein profile (analyzed by nuclear magnetic resonance) in patients with lung cancer (LC) or head and neck cancer (HNC), and the effects produced thereon by radiotherapy (RT). We included 33 patients with LC and 28 patients with HNC. Before irradiation, and one month after completion of RT, blood samples were obtained. The control group was composed of 50 healthy subjects. Patients had significantly lower serum PON1 activity and concentration before RT than the control group. PON1-related variables were good predictors of the presence of LC or HNC, with analytical sensitivities and specificities greater than 80%. Patients showed a significant increase in the number of particles of all subclasses of very-low-density lipoproteins (large, medium and small). However, these changes were not maintained when adjusted for age, sex, and other clinical and demographic variables. Irradiation was associated with a significant increase in PON1 concentration and, only in patients with HNC, with an increase in high-density lipoprotein-cholesterol concentration. Our results suggest that determinations of the levels of PON1-related variables may constitute good biomarkers for the evaluation of these diseases. Studies with a larger number of patients are needed to fully confirm this hypothesis
Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
licence for use: thttps://creativecommons.org/licenses/by/3.0/es/
ISSN: 20763921
Author's mail: monica.arguis@urv.cat mauricio.murcia@urv.cat jorge.camps@urv.cat xavier.correig@urv.cat jorge.joven@urv.cat meritxell.arenas@urv.cat mauricio.murcia@urv.cat
Author identifier: 0000-0002-3165-3640 0000-0002-6902-3054 0000-0003-2749-4541 0000-0003-0815-2570
Record's date: 2024-01-13
Journal volume: 8
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2076-3921/8/7/213
Papper original source: Antioxidants. 8 (7):
APA: Rodriguez-Tomas, Elisabet; Murcia, Mauricio; Arenas, Meritxell; Arguis, Monica; Gil, Miriam; Amigo, Nuria; Correig, Xavier; Torres, Laura; Sabater, Se (2019). Serum Paraoxonase-1-Related Variables and Lipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect of Radiotherapy. Antioxidants, 8(7), -. DOI: 10.3390/antiox8070213
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/antiox8070213
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV