Articles producció científica> Medicina i Cirurgia

Serum Paraoxonase-1-Related Variables and Lipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect of Radiotherapy

  • Datos identificativos

    Identificador: imarina:5813016
    Autores:
    Rodriguez-Tomas, ElisabetMurcia, MauricioArenas, MeritxellArguis, MonicaGil, MiriamAmigo, NuriaCorreig, XavierTorres, LauraSabater, SebastiaBaiges-Gaya, GerardCabre, NoemiLuciano-Mateo, FedraHernandez-Aguilera, AnnaFort-Gallifa, IsabelCamps, JordiJoven, Jorge
    Resumen:
    We investigated alterations in the levels of the antioxidant paraoxonase-1 (PON1) and the lipoprotein profile (analyzed by nuclear magnetic resonance) in patients with lung cancer (LC) or head and neck cancer (HNC), and the effects produced thereon by radiotherapy (RT). We included 33 patients with LC and 28 patients with HNC. Before irradiation, and one month after completion of RT, blood samples were obtained. The control group was composed of 50 healthy subjects. Patients had significantly lower serum PON1 activity and concentration before RT than the control group. PON1-related variables were good predictors of the presence of LC or HNC, with analytical sensitivities and specificities greater than 80%. Patients showed a significant increase in the number of particles of all subclasses of very-low-density lipoproteins (large, medium and small). However, these changes were not maintained when adjusted for age, sex, and other clinical and demographic variables. Irradiation was associated with a significant increase in PON1 concentration and, only in patients with HNC, with an increase in high-density lipoprotein-cholesterol concentration. Our results suggest that determinations of the levels of PON1-related variables may constitute good biomarkers for the evaluation of these diseases. Studies with a larger number of patients are needed to fully confirm this hypothesis
  • Otros:

    Autor según el artículo: Rodriguez-Tomas, Elisabet; Murcia, Mauricio; Arenas, Meritxell; Arguis, Monica; Gil, Miriam; Amigo, Nuria; Correig, Xavier; Torres, Laura; Sabater, Sebastia; Baiges-Gaya, Gerard; Cabre, Noemi; Luciano-Mateo, Fedra; Hernandez-Aguilera, Anna; Fort-Gallifa, Isabel; Camps, Jordi; Joven, Jorge;
    Departamento: Medicina i Cirurgia Enginyeria Electrònica, Elèctrica i Automàtica
    e-ISSN: 2076-3921
    Autor/es de la URV: Arenas Prat, Meritxell / Arguis Pinel, Mònica / Camps Andreu, Jorge / Correig Blanchar, Francesc Xavier / Joven Maried, Jorge / Murcia Mejia, Mauricio
    Palabras clave: Radiotherapy Paraoxonase-1 Lung cancer Lipoproteins Head and neck cancer Antioxidants paraoxonase-1 lung cancer lipoproteins head and neck cancer antioxidants
    Resumen: We investigated alterations in the levels of the antioxidant paraoxonase-1 (PON1) and the lipoprotein profile (analyzed by nuclear magnetic resonance) in patients with lung cancer (LC) or head and neck cancer (HNC), and the effects produced thereon by radiotherapy (RT). We included 33 patients with LC and 28 patients with HNC. Before irradiation, and one month after completion of RT, blood samples were obtained. The control group was composed of 50 healthy subjects. Patients had significantly lower serum PON1 activity and concentration before RT than the control group. PON1-related variables were good predictors of the presence of LC or HNC, with analytical sensitivities and specificities greater than 80%. Patients showed a significant increase in the number of particles of all subclasses of very-low-density lipoproteins (large, medium and small). However, these changes were not maintained when adjusted for age, sex, and other clinical and demographic variables. Irradiation was associated with a significant increase in PON1 concentration and, only in patients with HNC, with an increase in high-density lipoprotein-cholesterol concentration. Our results suggest that determinations of the levels of PON1-related variables may constitute good biomarkers for the evaluation of these diseases. Studies with a larger number of patients are needed to fully confirm this hypothesis
    Áreas temáticas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
    Acceso a la licencia de uso: thttps://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20763921
    Direcció de correo del autor: monica.arguis@urv.cat mauricio.murcia@urv.cat jorge.camps@urv.cat xavier.correig@urv.cat jorge.joven@urv.cat meritxell.arenas@urv.cat mauricio.murcia@urv.cat
    Identificador del autor: 0000-0002-3165-3640 0000-0002-6902-3054 0000-0003-2749-4541 0000-0003-0815-2570
    Fecha de alta del registro: 2024-01-13
    Volumen de revista: 8
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Referencia al articulo segun fuente origial: Antioxidants. 8 (7):
    Referencia de l'ítem segons les normes APA: Rodriguez-Tomas, Elisabet; Murcia, Mauricio; Arenas, Meritxell; Arguis, Monica; Gil, Miriam; Amigo, Nuria; Correig, Xavier; Torres, Laura; Sabater, Se (2019). Serum Paraoxonase-1-Related Variables and Lipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect of Radiotherapy. Antioxidants, 8(7), -. DOI: 10.3390/antiox8070213
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science,Food Science & Technology,Molecular Biology,Physiology
    Radiotherapy
    Paraoxonase-1
    Lung cancer
    Lipoproteins
    Head and neck cancer
    Antioxidants
    paraoxonase-1
    lung cancer
    lipoproteins
    head and neck cancer
    antioxidants
    Química
    Physiology
    Molecular biology
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias ii
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
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